Nowadays in orthopedic surgery -in the treatment of bone and soft tissue infectionsthere is an increasing claim for improving biodegradable drug delivery systems that can be easily placed into the site of application instead of the currently applied polymethylmethacrylate (PMMA) bone cements, since PMMA has some undesirable side effects. Therefore the aim of the study was to develop an injectab...

The increasing amount of plastic littered into the sea may provide a new substratum for benthic organisms. These marine fouling communities on plastic have not received much scientific attention. We present, to our knowledge, the first comprehensive analysis of their macroscopic community composition, their primary production and the polymer degradation comparing conventional polyethylene (PE) ...

There is a significant medical need for tough biodegradable polymer adhesives that can adapt to or recover from various mechanical deformations while remaining strongly attached to the underlying tissue. We approached this problem by using a polymer poly(glycerol-co-sebacate acrylate) and modifying the surface to mimic the nanotopography of gecko feet, which allows attachment to vertical surfac...

Biodegradable scaffolds play a critical role in therapeutic tissue engineering, in which the matrix degradation and tissue ingrowth are of particular importance for determining the ongoing performance of tissue-scaffold system during regenerative process. This paper aims to explore the mechanobiological process within biodegradable scaffolds, where the representative volume element (RVE) is ext...

A new type of in vivo tissue engineering system for tendon repair in situ after cut or crush of a flexor tendon is described. The system is based on the topographical reaction, alignment, migration and perhaps proliferation of tendon cells on micrometrically grooved substrates made in a biodegradable polymer. Macrophage trapping in the structure may also help to prevent inflammation. Tendon dam...

A starch-urea-based biodegradable coordination polymer modified by transition metal Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) was prepared by polycondensation of starch and urea. All the synthesized polymeric compounds were characterized by Fourier transform-infrared spectroscopy (FT-IR), (1)H-NMR spectroscopy, (13)C-NMR spectroscopy, UV-visible spectra, magnetic moment measurements, different...

Dental implants of tinidazole were formulated using poly (ε-caprolactone), a biodegradable polymer and evaluated. Clinical evaluation was carried out in ten patients with acute peridontitis. Various clinical parameters viz., gingival index, plaque score, attachment gain, reduction in pocket depth were evaluated after 10, 20, 30 and 40 days of treatment and compared with placebo as control. Ther...

We report the self-assembly of a biodegradable platinum nanoparticle-loaded stomatocyte nanomotor containing both PEG-b-PCL and PEG-b-PS as a potential candidate for anticancer drug delivery. Well-defined stomatocyte structures could be formed even after incorporation of 50% PEG-b-PCL polymer. Demixing of the two polymers was expected at high percentage of semicrystalline poly(ε-caprolactone) (...

Direct laser writing has been utilized to fabricate highly photostable fluorescent nanocluster microstructures in an organic polymer poly(methacrylic acid), where the carboxyl functional group is reported to play a vital role in nanocluster stabilization. In this Letter, we demonstrate that not only the polymer containing the carboxyl functional group, but also the polymer comprising the hydrox...

Thermoplastic biodegradable polymers displaying elastomeric behavior and mechanical consistency are greatly appreciated for the regeneration of soft tissues and for various medical devices. However, while the selection of a suitable base material is determined by mechanical and biodegradation considerations, it is the surface properties of the biomaterial that are responsible for the biological...