نتایج جستجو برای: beta cells
تعداد نتایج: 1519906 فیلتر نتایج به سال:
Background: The characteristic of stem cells in self renewal and differentiation to different types of cells has stimulated the interests for using stem cells as a starting material for generating insulin secreting cells. We've evaluated the differentiation potential of Programmable cells of monocytic origin (PCMOs) into insulin producing cells effected from the growth factors and fibroblasts c...
Background: The prevalence of type 2 diabetes is rapidly increasing in the world. As a result of this disease, long-term insulin resistance develops, as a result of which pancreatic beta cells are destroyed and disappear, as a result insulin is not released. Recently, a protein called lipasin, which is responsible for signaling the liver to beta cells, has been discovered, and previous reports ...
The two widely coexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid sequence. The beta-arrestins bind phosphorylated heptahelical receptors to desensitize and target them to clathrin-coated pits for endocytosis. To better define differences in the roles of beta-arrestin 1 and 2, we prepared mouse embryonic fibroblasts from knockout mice that lack...
background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...
objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...
Background: Phytoestrogens, a group of plant-derived polyphenolic compounds have recently come into considerable attention due to the increasing information on their potential adverse effects in human health. Some of phytoestrogens show estrogenic activity that may be carcinogenic for human. In the present study, we investigated the transcriptional effects of variety of phytoestrogens ...
Background Follicle stimulating hormone (FSH)- a hetrodimeric glycoprotein- is secreted by pituitary gland. This hormone stimulates growth and maturation of the follicles in females and sperms in male. Up to now, glycoprotein hormones such as FSH have produced in different cell lines. Among of the mammalian expression systems, the Chinese hamster ovary cells (CHO) have taken into consideration ...
Strychnos camptoneura (Loganiaceae) is used in Congolese traditional medicine to treat various diseases such as malaria and diabetes, but not much known about its effects on the immune system. Therefore, purpose of this study was investigate immunomodulatory properties S. leaves. Mice were treated with aqueous extract leaves (100 200 mg/kg); those administered reverse osmosis water β-1,3-g...
هدف اصلی تحقیق حاضر تحلیل اجتماعی خشونت شوهران علیه زنان می باشد. روش تحقیق، پیمایشی و ابزار جمع آوری اطلاعات پرسشنامه بوده است. جامعه آماری تحقیق، متشکل از کلیه زنان 45-15 ساله متاهل ساکن شهر سنندج می باشد. در مجموع 400 نفر از این زنان به روش نمونه گیری خوشه ای چند مرحله ای انتخاب شدند. چهارچوب نظری تحقیق متشکل از نظریات منابع و فمنیسم رادیکال می باشد.?متغیرهای مستقل?این تحقیق که در پی تبیین م...
Background and Aims: TGF-β is an effective cytokine in the viral replication cycle, which is also highly relevant to the pathogenesis of some viral infections. TGF-β induction by viral proteins is one of the ways to escape the virus from the immune system by inhibiting interferon signaling and other immune system factors. In recent years, the role of TGF-β and its inhibitor...
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