Dry eye disease (DED) is a common chronic ophthalmic disorder, and there no effective treatment to cure it. It urgent find new antidry compounds. Here, the effects underlying mechanisms of tilapia skin peptides (TSP) on DED were investigated. In vitro, human corneal epithelial cells (HCECs) cultured in hypertonic medium containing TSP for 12 h. The MTT assay, calcein-AM/PI staining, reactive ox...