Screening by a double-disk synergy test identified a Pseudomonas aeruginosa isolate that produced a clavulanic acid-inhibited expanded-spectrum beta-lactamase (ESBL). Cloning and sequencing identified a novel ESBL, BEL-1, weakly related to other Ambler class A ESBLs. beta-Lactamase BEL-1 hydrolyzed significantly most expanded-spectrum cephalosporins and aztreonam, and its activity was inhibited...

Title: Correction of self-reported BMI based on objective measurements: a Belgian experience Authors: Sabine Drieskens ([email protected]) Stefaan Demarest ([email protected]) Sarah Bel ([email protected]) Karin De Ridder ([email protected]) Jean Tafforeau ([email protected]) Version: 1 Date: 23 Oct 2017 Author’s response to reviews: Comments N Chau (revie...

Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexes were characterized by IR, NMR, and HRMS. The synthesized compounds were screened for their cyto...

N, Nbis(2-chloroethyl)aminobenzoyl picolinoyl hydrazide(BABPH), a benzoic acid nitrogen mustard based new compound and its metal complexes(Cu2+ and Zn2+) have been synthesized and characterized by elemental analysis, IR, 1HNMR, EPR, electronic spectrum, and molar conductivity measurements. In the present study, both BABPH and its complexes exhibited in vitro excellent inhibition of L1210, K562 ...

Acute postprandial gastric dilatation and associated clostridial enteritis necroticans is a well recognised but unusual clinical condition. Non-pathological overeating, gastric distension, and clostridial enteritis, termed pig-bel, has been reported in Papua, New Guinea. A similar condition (Darmbrand) was reported from Germany after the second world war, but it is not a condition seen in our s...

A series of novel N-anilino-5-methyl-2-(3-(5-(alkylaminomethyl)furan-2-yl-methylthio)propyl)-[1,2,4]triazolo-[1,5-a]pyrimidine-7-amine derivatives were synthesized and evaluated for their in vitro cytotoxicity against two cancer cell lines, Bel-7402 and HT-1080. Compounds 9, 14, 19 and 23 possessed marked cytotoxicity, especially 23 (with IC(50) values of 15.0 microM and 7.8 microM against Bel-...