The effects of bimatoprost on aqueous humor dynamics were quantified in monkey eyes. Uveoscleral outflow was measured by the anterior chamber perfusion method, using FITC-dextran. Total outflow facility was determined by the two-level constant pressure method. Aqueous flow was measured with a scanning ocular fluorophotometer. Uveoscleral outflow was 0.96 +/- 0.19 muL min(-1) in vehicle-treated ...

Ouabain was injected into the vitreous humor of one eye of rabbits in doses of 0.1, 0.2 and 0.5 meg. Aqueous humor inflow in the injected eye was inhibited significantly 49, 51, and 78 per cent, respectively, in these three dose groups 4 to 5 days after injection. In vitro Na-K activated ATPase activity of the ciliary body was inhibited significantly by 24, 16, and 27 per cent, corresponding to...

PURPOSE To evaluate whether the content of ascorbic acid in the corneal epithelium and aqueous humor reflects seasonal fluctuations in parallel with environmental changes. METHODS Reindeer, cattle, rabbits, and humans were examined, to cover a broad spectrum of overlapping habitats. Ascorbic acid was determined by high-performance liquid chromatography. The thickness of the corneal epithelium...

The topical application of reseipine and the benzoquinolizine Ro 4-1284 to rabbit eyes leads to a significant depression of the intraocular pressure. This reduction is d,ue essentially to a depression of the formation rate and is counteracted by a small drop in facility of ouifiow. As in other biologic systems, the action of reserpine lasts longer and requires lower concentrations than that of ...

Methods. Mature TGF-/?2 levels were determined in aqueous humor samples of 9 patients with Fuchs' heterochromic cyclitis, aqueous humor samples of 21 patients with other uveitis entities, and vitreous fluid samples of 19 patients with uveitis by using a commercially available sandwich ELISA. Total TGF-/?2 levels in ocular fluids were measured after heat activation. Aqueous humor samples from pa...

The patient was a 65‐year‐old man who had undergone cataract surgery. Owing to a minor Descemet’s membrane detachment in the frontal part of the main wound, an air bubble was injected into the anterior chamber (AC) of the eye. On postoperative day (POD) 1, approximately 50% of the AC consisted of air, and the AC cells were reported to be 2 plus. On POD 2, the patient was referred to the clinic ...

THE recent article by Duke-Elder and Davsohn,1 discussing the work on aqueous humour dynamics by Kinsey, Grant and Cdgan,2 provides the opportunity for an exchange. of views on this subject; which, I 'believe,. will show that the area of agreement among workers 'in this field is now very much greater than the area still in dispute. There is apparently general agreement that some exchange of con...

The ciliary epithelium of the eye secretes the aqueous humor. It is a double epithelium arranged so that the apical surfaces of the nonpigmented ciliary epithelial (NPCE) and pigmented ciliary epithelial (PCE) cells face each other and the basolateral membranes face the inside of the eye and the blood, respectively. We have investigated the volume responses of both single cells and coupled pair...

THE investigation was undertaken to establish the cause of the decrease in intra-ocular pressure induced in normal rabbits by 2-acetylamino-1, 3, 4 thiadiazole 5-sulphonamidet, an inhibitor of the enzyme carbonic anhydrase. At the same time, it was hoped that a comparison of these results with the known ability ofDiamox to reduce the intra-ocular pressure in glaucomatous patients for extensive ...

By using a highly sensitive and specific radioimmunoassay and the slot-blot technique, transferrin was quantified in fresh samples of aqueous humor from patients with primary open-angle glaucoma (POAG, n = 36) or secondary glaucoma (SG, n = 18). The levels were compared with those in aqueous humor obtained from age-matched patients without glaucoma (n = 33) and in primary and secondary aqueous ...