Background: Prostate cancer (Pca) is a heterogeneous disease, and current treatments are not based on molecular stratification. Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors have recently been found to be remarkably toxic to cells with defects in homologous recombination, particularly cells with BRCA-mutated backgrounds. Therefore, this preliminary study was designed to ...

Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

Aim The aim of this study was to examine the potential ameliorative effects caffeic acid (CA) on hydrogen peroxide (H2O2)-induced neurodegeneration in a human SH-SY5Y cell line, as well possible mechanisms involved. Method Cell proliferation evaluated by WST-1 assay. apoptotic index calculated TUNEL Assay. Antioxidant parameters were studied measuring reactive oxygen species (ROS), lipid peroxi...

Apoptosis or programmed cell death is a standard physiological mechanism. It essential to control the number of cells, balance division and death, regulate immune system, eliminate pathogen-infected cells. entailed different investigation determine related biochemical reactions such as activated caspase, Reactive Oxygen Species (ROS), Lipid Peroxidation (LPO), Evaluation Glutathione Content (GS...

Background and Aims: Natural compounds derived from animal, plant, and microbial sources participate in treating various types of cancers, including lung cancer. This survey attempted to explore the anticancer activity of two novel metabolites extracted from soil-derived actinomycetes in the human lung cancer A549 cells. Materials and Methods: The crude extracts of UTMC 638 and UTMC 877 second...

conclusions in our study, no prominent effect was seen; therefore, in order to have a better perspective of crocin activity against cancerous cell lines, further studies are highly recommended. results the highest concentration of crocin significantly decreased ros production after 48 hours of treatment. however, crocin had no effect on the expression level of hsp (heat shock protein). addition...

Rosmarinus officinalis L., a medicinal herb from the labiates family, has been reported to be of potential benefit in the treatment and prevention of several diseases. In particular its phenolics have demonstrated protective effects on various types of cancer through several mechanisms. The present study aimed to determine the effects of rosemary phenolic extracts on human cell functions, with ...

objective: extracellular deposition of the beta-amyloid (aβ) peptide, which is the main finding in the pathophysiology of alzheimer’s disease (ad), leads to oxidative damage and apoptosis in neurons. melissa officinalis (m. officinalis) is a medicinal plant from the lamiaceae family that has neuroprotective activity. in the present study we have investigated the protective effect of the acidic ...