نتایج جستجو برای: anti rejection therapy

تعداد نتایج: 996561  

Journal: :Journal of immunology 2011
Audrea M Burns Anita S Chong

Circulating alloantibodies in transplant recipients are often associated with increased Ab-mediated as well as cellular rejection. We tested the hypothesis that alloantibodies facilitate cellular rejection by functioning as opsonins to enhance T cell activation using a BALB/c to C57BL/6 heart or skin transplant model. Long-term heart and skin survival induced with anti-CD154 alone or in combina...

Journal: :Transplant immunology 2011
Helong Dai Jibing Chen Wei Shao Feng Wang Shuo Xu Yuanzheng Peng Yingying Lin Junjie Xia Henrik Ekberg Xiaomin Wang Zhongquan Qi

BACKGROUND Alloreactive memory T cells are a major obstacle to transplantation acceptance due to their capacity for accelerated rejection. METHODS C57BL/6 mice that had rejected BALB/c skin grafts 4 weeks earlier were used as recipients. The recipient mice were treated with anti-CD154/LFA-1 with or without anti-CD70 during the primary skin transplantation and anti-CD154/LFA-1 or not during th...

Journal: :Nephron 1987
R D Gordon T E Starzl J J Fung S Iwatsuki C O Esquivel A Tzakis S Todo

Thirty-six ciclosporin-prednisone-treated recipients of nonmatched cadaver renal allografts were given a course of Orthoclone OKT3 monoclonal antibody for steroid-resistant cell-mediated rejection. Although side effects were common, only 2 patients had to be withdrawn from therapy and there were no deaths related to therapy. Twenty-three (63.9%) allografts were rescued with OKT3 therapy and 21 ...

Journal: :World journal of transplantation 2012
Hari Varun Kalluri Karen L Hardinger

For kidney transplant recipients, immunosuppression commonly consists of combination treatment with a calcineurin inhibitor, an antiproliferative agent and a corticosteroid. Many medical centers use a sequential immunosuppression regimen where an induction agent, either an anti-thymocyte globulin or interleukin-2 receptor antibody, is given at the time of transplantation to prevent early acute ...

2014
John C Mullen Emily J Kuurstra Antigone Oreopoulos Michael J Bentley Shaohua Wang

BACKGROUND The purpose of this study was to test the efficacy and safety of daclizumab (DZM) versus anti-thymocyte globulin (ATG) as a component of induction therapy in heart transplant recipients. METHODS Thirty heart transplant patients were randomized to receive either ATG or DZM during induction therapy. Patients in the DZM group received an initial dose of 2 mg/kg intravenous (IV) at the...

Journal: :Transplantation 2003
Krista G Haanstra Jan Ringers Ella A Sick Seema Ramdien-Murli Eva-Maria Kuhn Louis Boon Margreet Jonker

BACKGROUND Costimulation blockade has been proposed to induce allograft tolerance. We combined an antagonist anti-CD40 monoclonal antibody (mAb) with an antagonist anti-CD86 mAb in a rhesus monkey kidney allograft model. We chose this combination because it leaves CD80-CD152 signaling unimpaired, allowing for the down-regulatory effect of CD152 signaling to take place through this pathway. ME...

رضائی, سید عبدالرحیم, میراحمدیان, ماهرو, نیک بین, بهروز,

For monitoring of renal transplant function, serum B2m was evaluated in 23 recipients. According to clinical diagnosis the patients were in four groups: 1) Successful renal transplant the mean concentration of SB2m pretransplantation was 73.1±26.1 mg/L but decreased to nearly normal level (4.43±1.17 mg/L) within 24-48h and then reached to 3.1 mg/L duting 20 days after transplantation. 2) Renal ...

Journal: :Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2012
Osama Gheith Torki Al-Otaibi Narayanan Nampoory Medhat Halim Prasad Nair Tarek Saied Salah Al-Waheeb Ibraheem Muzeirei Mona Ibraheim

To reduce the long-term toxicities of immunosuppressant drugs, corticosteroid-sparing and calcineurin-inhibitor-sparing immunosuppression protocols have become increasingly popular in managing kidney transplant recipients. The most vexing clinical condition caused by antibodies in organ transplants is antibody-mediated rejection. Limitations of the current antibody-mediated rejection therapies ...

Journal: :Circulation 1992
M Isobe J Narula J F Southern H W Strauss B A Khaw E Haber

BACKGROUND Mice with abdominal heterotopic heart transplants were studied to determine whether scintigraphic detection of an increase in major histocompatibility complex (MHC) class II antigen expression could be used as a noninvasive method for diagnosing early rejection. METHODS AND RESULTS Allografts from C3H/He (H2k) donors were transplanted into BALB/c (H2d) recipients (n = 18). Two of t...

Journal: :modares journal of medical sciences: pathobiology 2011
fatemeh safarian fatemeh rahbarizadeh said amanpour zahra sharifzadeh

objective: the objective of this study is to develop and assess targeted pamam-peg nanocarrier with anti-tag72 nanobody for t-bid gene coding construct delivery into the human colonic adenocarcinoma cells. materials and methods: nanobody (nb) coding sequence was subcloned into psj expression vector for large-scale production and then nb was purified by ni++ affinity chromatography. sds-page an...

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