A series of substituted aryl glycoside analogues of gastrodin have been identified as potential anti-influenza agents. The most potent inhibitor 1a exhibited moderate inhibitory activity against the A/Hanfang/359/95(H3N2) and A/FM/1/47(H1N1) strains of the influenza A virus (IC(50) values of 44.40 and 34.45 μM, respectively) and the oseltamivir-null B/Jifang/13/97 strain of influenza B (IC(50) ...

Abstract Despite the success in development of antiviral drugs, a need continues to exist for effective therapies for viral infections. Proteinase inhibitors of microbial origin could be used successfully as antiviral agents. The virus-inhibitory activity of a fermentation product, produced by Streptomyces sp. 225b (SS 225) was studied with respect to the specificity and selectivity of inhibiti...

background : uncontrolled and irrational use of antibiotics increases the rate of antimicrobial resistance and treatment failure. compliance with antibiotics is an important indicator to show how patients use their prescribed drugs and it can explain the relationship between drug administration and treatment outcome that needs to be monitored and promoted. we decided to evaluate compliance to a...

objective(s) the effect of testosterone on anxiety-like behaviors has been the subject of some studies. there is evidence that testosterone modulates anxiety via gaba (gama aminobutyric acid) and gabaergic system. the involvement of gabac receptors in those effects of testosterone on anxiety-like behaviors of the rats was investigated in the present study. materials and methods a group of rats ...

background: central venous (cv) catheters play an essential role in the management of critically ill patients in the intensive care unit (icu). cv lines are, however, allied to catheter-associated blood stream infections. bacterial colonization of cv lines is deemed the main cause of catheter-associated infection. the purpose of our study was to compare bacterial colony counts in the catheter s...

bacterial sepsis is one of the most common causes of mortality and morbidity in neonates. it has been recognized a gradual change in spectrum of organisms responsible for neonatal sepsis. in this study we have evaluated changing trend of incidence and antibiotic susceptibility in neonatal late - onset sepsis (los) in 2-periods. this study is based on results of blood culture in neonatal late-on...

just regarding different risk factors for antibiotic resistant uropathogenes, it seems justice to improve diagnostic power for drug resistant uropathogenes and well appropriate empirical therapy. 300 and 145 cases of clinicopathologically diagnosed nosocomial and spinal cord injured (sci) associated urinary tract infection (uti), respectively, were considered as our samples included in our 24 m...

conclusions: according to our experiment, onion has an inhibitory effect on the growth of normal eye flora; although the duration of onion juice instillation did not show any significant effect on the group results. hence, this finding is an initiating point for further investigations into the antimicrobial properties of this herb to treat common eye infections, including conjunctivitis and ble...