نتایج جستجو برای: anergy

تعداد نتایج: 1795  

Journal: :Journal of immunology 2006
Juyang Kim Woon S Choi Hyun Kang Hye J Kim Jae-Hee Suh Shimon Sakaguchi Byungsuk Kwon

In this study, we investigated the effect of an agonistic mAb (DTA-1) against glucocorticoid-induced TNF receptor (GITR) in a murine model of systemic lupus erythematosus-like chronic graft-vs-host disease (cGVHD). A single dose of DTA-1 inhibited the production of anti-DNA IgG1 autoantibody and the development of glomerulonephritis, typical symptoms of cGVHD. DTA-1-treated mice showed clinical...

2013
Mohammad Aslam Yusuke Kishi Takeshi Tsubata Jennifer Marshall David Nemazee Marko Radic

CD40L, a member of the tumor necrosis factor (TNF) ligand family, is overexpressed in patients with systemic lupus erythematosus and in lupus mouse models. Previously, we demonstrated that B cells producing pathogenic anti-Sm/RNP antibodies are deleted in the splenic marginal zone (MZ), and that MZ deletion of these self-reactive B cells is reversed by excess CD40L, leading to autoantibody prod...

Journal: :Blood 2008
Paul E Zarek Ching-Tai Huang Eric R Lutz Jeanne Kowalski Maureen R Horton Joel Linden Charles G Drake Jonathan D Powell

Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important negative regulator of T-cell function. In this report, we demonstrate that A(2A)R stimulation not only inhibits the generation of adaptive effector T cells but also promotes the induction of adaptive regulatory T cells. In vitro, antigen recognition in the setting of A(2A)R engagement induces...

Journal: :Journal of immunology 2002
Barbara J Vilen Kathy M Burke Michelle Sleater John C Cambier

B cell tolerance can be maintained by functional inactivation, or anergy, wherein B cell Ag receptors (BCR) remain capable of binding Ag, but are unable to transduce signals. Although the molecular mechanisms underlying this unresponsiveness are unknown, some models of B cell anergy are characterized by disruption of proximal BCR signaling events, and by destabilization of the BCR complex. Rece...

Journal: :Journal of immunology 2013
Zhong-Bin Deng Xiaoying Zhuang Songwen Ju Xiaoyu Xiang Jingyao Mu Yuelong Liu Hong Jiang Lifeng Zhang James Mobley Craig McClain Wenke Feng William Grizzle Jun Yan Donald Miller Mitchell Kronenberg Huang-Ge Zhang

Regulation and induction of anergy in NKT cells of the liver can inhibit autoimmune and antitumor responses by mechanisms that are poorly understood. We investigated the effects of PGE2, delivered by intestinal, mucus-derived, exosome-like nanoparticles (IDENs), on NKT cells in mice. In this study, we demonstrate that IDENs migrate to the liver where they induce NKT cell anergy. These effects w...

2015
Špela Magister Han-Ching Tseng Vickie T. Bui Janko Kos Anahid Jewett

Freshly isolated human primary NK cells induce preferential lysis of Oral Squamous Carcinoma Stem Cells (OSCSCs) when compared to differentiated Oral Squamous Carcinoma Cells (OSCCs), while anti-CD16 antibody and monocytes induce functional split anergy in primary NK cells by decreasing the cytotoxic function of NK cells and increasing the release of IFN-γ. Since NK92 cells have relatively lowe...

Journal: :Immunology letters 2002
Hironori Kudo Takako Matsuoka Hiroaki Mitsuya Yasuharu Nishimura Sho Matsushita

HLA class II molecules play pivotal roles in antigen presentation to CD4+ T cells. We investigated signaling via HLA-DR molecules expressed on CD4+ T cells. When HLA-DR or CD3 molecules on cloned CD4+ T cells were cross-linked by solid-phase mAbs, T cells proliferated, and this resulted in anergy. Whereas cross-linking of HLA-DR and CD3 resulted in secretion of the same levels of IFN-gamma and ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Julio C Delgado Eunice Y Tsai Sok Thim Andres Baena Vassiliki A Boussiotis Jean-Marc Reynes Sun Sath Pierre Grosjean Edmond J Yunis Anne E Goldfeld

Purified protein derivative (PPD) skin testing is used to identify persons infected with Mycobacterium tuberculosis (Mtb) and to assess cell-mediated immune responses to Mtb. However, lack of skin induration to intradermal injection of PPD or PPD anergy is observed in a subset of patients with active tuberculosis (TB). To investigate the sensitivity and persistence of PPD reactivity and its in ...

Journal: :PLoS ONE 2007
Xiao Xiao Jenny Gu Feng Yun Yue Colin M. Kovacs Mario A. Ostrowski

BACKGROUND HIV specific T cells are putatively anergic in vivo. IL-2, a member of a class of cytokines that binds to receptors containing the common gamma chain (gammac) has been shown to reverse anergy. We examined the role of gammac cytokines in reversing HIV specific T cell anergy. METHODS PBMC from untreated HIV-infected individuals were briefly exposed to a panel of gammac cytokines, and...

Journal: :The Journal of Experimental Medicine 1993
M J Rapoport A H Lazarus A Jaramillo E Speck T L Delovitch

Thymic T cell anergy, as manifested by thymocyte proliferative unresponsiveness to antigens expressed in the thymic environment, is commonly believed to mediate the acquisition of immunological self-tolerance. However, we previously found that thymic T cell anergy may lead to the breakdown of tolerance and predispose to autoimmunity in nonobese diabetic (NOD) mice. Here, we show that NOD thymic...

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