Atomic force microscopy is a powerful characterization tool for polymer science, capable of revealing surface structures with superior spatial resolution [1]. The universal character of repulsive forces between the tip and the sample, which are employed for surface analysis in AFM, enables examination of even single polymer molecules without disturbance of their integrity [2]. Being initially d...

Atomic force microscopy (AFM) enables the pick up of a single protein molecule to apply a mechanical force. This technique, called "force spectroscopy," provides unique information about the intermediates and free energy landscape of the mechanical unfolding of proteins. In this review, we introduce the AFM-based single molecule force spectroscopy of proteins and describe recent studies that an...

This thesis looks at surface-bound nanowires and nanoparticles, the mechanical and the metrological properties of which are of practical importance in the realization of nanometer-scale electronics. Atomic force microscope (AFM) was the main instrument of research. By bending suspended carbon nanotube structures with the AFM, the Young’s modulus of carbon nanotubes has been measured. An efficie...

For sectioned biologic tissues, atomic force microscopy (AFM) topographic images alone hardly provide adequate information leading to revealing biological structures. We demonstrate that phase imaging in amplitude-modulation AFM is a powerful tool in mapping structures present on the surface of unfixed rat brains sections. The contrast in phase images is originated from the difference in mechan...

This paper describes an atomic force microscope (AFM) based voltage-assisted electrospinning technique. Single nanofibers on substrates are prepared via simultaneous preparation and deposition. In this work, an AFM-based electrospinning process is developed to generate polyethylene oxide (PEO) polymeric single fibers with nanometer scale diameters. The results demonstrate the feasibility of thi...

A new method based on combined atomic force microscopy (AFM) and fluorescence microscopy observations, is proposed to visualize the insertion of glycosylphosphatidyl inositol (GPI) anchored alkaline phosphatase from buffer solutions into supported phospholipid bilayers. The technique involves the use of 27 nm diameter fluorescent latex beads covalently coupled to the amine groups of proteins. F...

The recently developed AFM local anodic oxidation (LAO) technique offers a convenient way of patterning nanodevices, but imposes even more stringent requirements on the underlying quantum well structure. We developed a new very shallow quantum well design which allows the depth and density of the 2D gas to be independently controlled during the growth. A high mobility (0.5×106 cm2 V−1 s−1 at 4....

While the theoretical implications of models of DNA tile self-assembly have been extensively researched and such models have been used to design DNA tile systems for use in experiments, there has been little research testing the fundamental assumptions of those models. In this paper, we use direct observation of individual tile attachments and detachments of two DNA tile systems on a mica surfa...

Abrasive flow machining (AFM) is a manufacturing technique that uses the flow of a pressurized abrasive media to remove work piece material. In comparison with other polishing technique, AFM is very efficient, suitable for the finishing of complex inner surfaces. In recent years, hybrid-machining processes have been developed to improve the efficiency of a process by clubbing the advantages of ...

In this paper, we describe a new scanning technique for fast atomic force microscopy. In this method, the sample is scanned in a spiral pattern instead of the well established raster pattern. A spiral scan can be produced by applying single frequency cosine and sine signals with slowly varying amplitudes to the x-axis and y-axis of an atomic force microscope (AFM) scanner respectively. The use ...