نتایج جستجو برای: ad syndrome
تعداد نتایج: 703903 فیلتر نتایج به سال:
BACKGROUND Apathy is a complex multidimensional syndrome frequently reported in Alzheimer's disease (AD) and is associated with impaired awareness. Here we present a psychometrically robust method to profile apathy in AD. OBJECTIVES To determine the validity and reliability of a multidimensional apathy measure, the Dimensional Apathy Scale (DAS), and explore the apathy subtype profile and its...
INTRODUCTION A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings. METHODS Consensus statements about PCA were developed through a detailed literature review, the formation of an international multidisciplinary working party which convened on four occasions, and a Web-based quantit...
The diagnosis of Alzheimer's disease (AD) neurodegeneration is based on histopathological detection of paired helical filament-associated lesions. Silver stains are routinely used but the results are fraught with intra- and interinstitutional variability. This study employed monoclonal antibodies to middle and high molecular weight neurofilament subunits in an immunohistochemical assay to asses...
Beta-amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain. APP plays a central role in Alzheimer's disease (AD) pathogenesis: APP processing generates β-amyloid (Aβ) peptides, which are deposited as amyloid plaques in the brains of AD individuals; point mutations and duplications of APP are causal for a subset o...
the prevalence of atopic dermatitis (ad) and obesity have been increasing considerably in korean school-children. ad is a chronic pruritic recurrent inflammatory skin disorder. leptin is secreted by adipocytes which has been suggested to be immunologically active; however, their role in ad has not yet been well understood. a total of 227 subjects out of 2,109 elementary school children were def...
VOLUME 96, OCTOBER 2015 E7 WWW.CUTIS.COM To the Editor: Staphylococcal scalded skin syndrome (SSSS) is a superficial blistering disorder mediated by Staphylococcus aureus exfoliative toxins (ETs).1 It is rare in adults, but when diagnosed, it is often associated with renal failure, immunodeficiency, or overwhelming staphylococcal infection.2 We present a unique case of a pregnant woman with chr...
Expression of the Down syndrome critical region 1 (DSCR1) protein, an inhibitor of the Ca(2+)-dependent phosphatase calcineurin, is elevated in the brains of individuals with Down syndrome (DS) or Alzheimer's disease (AD). Although increased levels of DSCR1 were often observed to be deleterious to neuronal health, its beneficial effects against AD neuropathology have also been reported, and the...
Last century, in 1907, Alois Alzheimer first described the disease that now bears his name, relating a 54-year-old female case with presenile dementia. Alzheimer’s disease (AD), an irreversible progressive neurodegenerative disorder, is actually the most common form of dementia. AD affects more than 24 million people all over the world, and is predicted to double every 20 years, becoming one of...
هدف تحقیق حاضر، ارزیابی نقص توجه انتخابی در افراد مسن مبتلا به بیماری آلزایمـر و سالم با استفاده از روش تکلیف دوگانه بود. شرکت کنندگان شامل 23 فرد (11 زن و 12 مرد) با دامنه سنی 62 تا 81 سال که 13 نفر از آنها مبتلا به بیماری آلزایمر(ad) و10 نفر افراد مسن سالم(ec) که دارای عملکرد شناختی طبیعی بودند، در این مطالعه شرکت داشتند. شناسایی افراد مبتلا به آلزایمر و سالم بر اساس تشخیص پزشک و پرسشنامه وضع...
Neurodegenerative dementias are characterized by insidious onset and gradual progression of cognitive dysfunction, initially relatively focal with respect to cognitive domains and brain regions involved. Neuroimaging techniques have contributed enormously to both our understanding of large-scale network specificity in neurodegenerative syndromes and our ability to make clinical diagnoses of syn...
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