an investigation was carried out on a young unrelated couple, both 29 years old, with two boys and three girls, 3 months to 8 years old. one boy and the mother were healthy, the other four children and the father were affected. the family, originally from the district of nour, in northern iran, near the caspian sea, was first counseled at the genetic clinic in tehran in 1984. several trips were...

Alzheimer disease (AD) and metabolic syndrome are two highly prevalent pathological conditions of Western society due to incorrect diet, lifestyle, and vascular risk factors. Recent data have suggested metabolic syndrome as an independent risk factor for AD and pre-AD syndrome. Furthermore, biological plausibility for this relationship has been framed within the "metabolic cognitive syndrome" c...

OBJECTIVE To describe a case of young-onset Alzheimer disease (AD) due to mosaicism for trisomy 21. DESIGN Case report of a single patient. SETTING Tertiary referral dementia clinic. PATIENT A 55-year-old man with a mild degree of developmental delay but no previous diagnosis of Down syndrome and only minimal physical manifestations of Down syndrome presented with gradually progressive co...

Abstract Background The study of sex differences in Alzheimer's disease (AD) is gaining increasing attention. Yet, few studies have examined the effect genetically determined forms AD. Here, we explored impact on AD‐related clinical and biomarker changes a population‐based cohort adults with Down syndrome, who lifetime risk over 90% to develop Method This cross‐sectional 549 syndrome. We compar...

Neurodegenerative dementias that occur in adults can present with significant behavioral symptoms in addition to the cognitive syndrome. These can be disruptive for the families who take care for these patients and cause a significant burden on the medical system. The incidence of Alzheimer’s disease (AD) is frequently greater in patients over 65 years of age, whereas the behavioral variant of ...

Frontal variant-Frontotemporal dementia (fvFTD) and Alzheimer's disease (AD) patients matched for severity of dementia at the Clinical Dementia Rating (CDR) received neuropsychological testing in order to explore if the dysexecutive disorder might characterise fvFTD at early stage, when AD is dominated by the episodic memory defect. We also determined if the behavioural syndrome was more severe...

BACKGROUND The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. OBJECTIVES To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR ind...

Patients with autosomal-dominant (AD) hyper immunoglobulin E (IgE) syndrome (HIES) or Job syndrome develop frequent dermatologic and pulmonary infections. As patients have an extreme elevation of IgE levels, this database analysis study sought to study the association between AD HIES, Job syndrome, and anaphylaxis. HIES is a heterogeneous group of immune disorders characterized by extremely ele...

To determine the frequency of Alzheimer's disease (AD) pathology in patients presenting with progressive focal cortical syndromes, notably posterior cortical atrophy (PCA), corticobasal syndrome (CBS), behavioural variant frontotemporal dementia (bvFTD), progressive non-fluent aphasia (PNFA) (or a mixed aphasia) and semantic dementia (SD); and to compare the age of onset, evolution and prognosi...