Although toxoplasmosis is one of the most common parasitic infections worldwide, therapeutic options remain limited. Cathepsins, proteases that play key roles in the pathogenesis of toxoplasmosis and many other protozoan infections, are important potential therapeutic targets. Because both TgCPB and TgCPL play a role in T. gondii invasion, we evaluated the efficacy of the potent, irreversible v...

Methods The study included 407 non-pregnant women with high risk for toxoplasmosis, presented to the Infectious Diseases Clinic in Oradea in the period 01.01.2009-31.12.2012. By MEIA (Microparticle Enzyme Immunoassay) performed in Bioclinica laboratories, values of Toxoplasma IgM and IgG antibodies were determined and by EIA (Enzyme Immunoassay), the values of IgA Toxoplasma antibodies, as well...

We report two AIDS patients who developed acute renal failure while receiving sulphadiazine for cerebral toxoplasmosis. Renal ultrasound revealed diffuse bilateral echogenic shadowing material. 'Sheaves of wheat' crystals, typical of sulphadiazine crystalluria, were present in the urine. One patient required a percutaneous nephrostomy. Hydration and urine alkalinisation resulted in rapid improv...

Introduction : Toxoplasmosis, caused by Toxoplasma gondii, is a protozoan parasitic infection distributed worldwide. Early infection by this protozoa can lead to abortion and congenital toxoplasmosis in pregnant women. This study was conducted to determine the seroprevalence of T. gondii infection among pregnant women referring to Shahid Akbar Abadi Hospital, Tehran, Iran during 2010-2013. Meth...

Although human toxoplasmosis is a notifiable disease in Taiwan since 2007, little is known about its risk factors. This study aimed to investigate the risk factors for acute Toxoplasma gondii diseases in Taiwan. We conducted a nationwide population-based case-control study. Cases of acute human toxoplasmosis notified to the Taiwan Centers for Diseases Control (Taipei, Taiwan) during 2008-2013 w...

Pregnant women can be infected with TORCH (toxoplasmosis, other virus, rubella, cytomegalovirus and herpes) which have been linked to fetal or neonatal malformations. Toxoplasmosis is the most common of these infections. Toxoplasma is an intracellular parasite that is found in animals, including sheep and mice. It is transmitted in the feces of cats who have consumed infected mice and in meat f...

We report the detection of specific IgA antibodies and the determination of IgG avidity in sequential serum samples from a patient exhibiting significant levels of Toxoplasma-specific IgM antibodies for seven years after the onset of the clinical symptoms of toxoplasmosis. IgM antibodies were detected by an indirect immunofluorescence test and by three commercial enzyme-linked immunosorbent ass...

OBJECTIVE To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Bra...

Introduction Mrs M., a 30 year-old lecturer in psychology is expecting her second baby. Her first baby was born while she was on sabbatical in France. During that pregnancy she was screened for Toxoplasmosis, found to be non-immune and had repeated monthly screening throughout her pregnancy. The consensus in France is to screen all pregnant women for toxoplasmosis at the first visit, and to off...