Differentiation Syndrome (DS) has been identified in a subset of patients undergoing treatment with novel classes differentiating therapies for acute myeloid leukemia (AML) such as IDH and FLT3 inhibitors. While DS is well-known treatment-related complication promyelocytic (APL), efforts are still ongoing to standardize diagnostic parameters AML. Though the rates incidence vary, many signs symp...

Unlike other forms of AML, APL is less frequently diagnosed in the elderly and has a relatively favourable outcome. Elderly patients with APL seem at least as responsive to therapy as do younger patients, but rates of response and survival are lower in this age setting owing to a higher incidence of early deaths and deaths in remission when conventional treatment with ATRA and chemotherapy is u...

BACKGROUND The gastrointestinal tract is a rare site for extramedullary involvement in acute promyelocytic leukemia (APL). CASE REPORT A 43-year-old female with no past medical history presented complaining of mild abdominal pain, fever, and chills for the past day. On examination, she was tachycardic and febrile, with mild tenderness of her right lower quadrant and without signs of peritonea...

nvironmental research is being pursued in several areas at APL to understand the science of atmospheric and space processes and apply that knowledge to fi nding technological solutions to problems of interest to our sponsors. Two areas are specifi cally addressed in this article: (1) atmospheric, oceanic, and littoral environment research as it affects input to radar propagation codes, and (2) ...

ECG, electrocardiogram; CT, computed tomography; M1, acute myeloid leukemia without differentiation; WBC, white blood cells; WHO, World Health Organization; CK-MB, creatine kinase–myocardial band; CBC, complete blood count; APL, acute promyelocytic leukemia; AML, acute myelocytic leukemia; ALL, acute lymphocytic leukemia; CD, cluster of differentiation; HLA-DR, human leukocyte antigen–D related...

The authors report herein two diagnostically challenging cases centered on the myeloid/natural killer (myeloid/NK) cells, a variant of myeloblasts, to illustrate the importance of advanced flow cytometric immunophenotyping and an updated understanding of surface markers in hematopoietic malignancies. Myeloid/NK cell acute leukemia is a very rare subtype of leukemia. Although its NK-cell nature ...

This study reports a case of promyelocytic sarcoma that developed as a solitary sternal mass without any clinical evidence of acute promyelocytic leukemia. The case presented the diagnostic difficulties common to all aleukemic granulocytic sarcomas, and diagnosis was made possible by local identification of the PML/RARα fusion gene by fluorescent in situ hybridization. The patient was treated b...

OBJECTIVES We investigated the impact of secondary antiphospholipid syndrome (APS) and antiphospholipid antibody (aPL) positivity on the non-thromboembolic clinical manifestations of systemic lupus erythematosus (SLE). METHODS In total, 224 patients with SLE were studied, of whom 105 were aPL-positive; 52 fulfilled the criteria for APS. SLE- and APS-related clinical and laboratory features we...

Many infections have been found to be associated with antiphospholipid antibodies (aPL), although a pathogenic role for these antibodies has not usually been obvious except in a few isolated cases. Two types of aPL have been referred to as "autoimmune" and "infectious" types. This distinction, however, has subsequently been found not to be absolute.