Background The liver is a vital target for sepsis-related injury, leading to inflammatory pathogenesis, multiple organ dysfunction and high mortality rates. Monocyte-derived macrophage transformations are key events in hepatic inflammation. N1-[(4-methoxy)methyl]-4-methyl-1,2-benzenediamine (FC-99) previously displayed therapeutic potential on experimental sepsis. However, the underlying mechan...

Pregnancy is associated with altered liver function, particularly in serum enzymes. Anabolic steroids are responsible to some degree in mediating the physiologic and biochemical changes that occur during an uncomplicated pregnancy. However, several liver disorders are unique to pregnancy and include intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy, and hepatic dysfunction a...

Acute fatty liver of pregnancy (AFLP) is a potentially fatal metabolic disorder that manifests during the third trimester. Early diagnosis, termination of pregnancy, and treatment of complications associated with AFLP significantly reduce maternal morbidity and mortality. While most cases of AFLP occur before delivery, some may occur after vaginal delivery. Anesthesia providers should have a hi...

Background: Hepatitis B is a major global health problem. Chronic hepatitis characterized by hepatic inflammation, necrosis and persistence of HbsAg for at least 6 months. liver disease more predictably associated with impaired metabolism drugs than acute dysfunction. Prescribing in patients chronic challenging because concerns that the drug may exacerbate disease. There also fear altered state...

conclusions the article presents the relation between anemia and liver dysfunction viewed by iranian traditional medicine as an important finding in designing a treatment plan. despite the new findings on the evaluation of liver function (i.e. laboratory tests), it seems that further studies for earlier evaluation of liver function in anemia are highly required. results our findings proved that...

Acute liver failure (ALF) is a rare presentation of liver metastases. Although cases of ALF from metastatic disease have been reported, etiologies have been largely confined to lymphoma, metastatic breast, lung, and gastric cancers. ALF from medullary thyroid cancer (MTC) has never been reported. We present a 59-year-old male with newly diagnosed MTC, who was admitted with ALF. He presented wit...

The liver, the largest organ with multiple synthesis and secretion functions in mammals, consists of hepatocytes and Kupffer, stem, endothelial, stellate and other parenchymal cells. Because of early and extensive contact with the external environment, hepatic ischaemia reperfusion (IR) may result in mitochondrial dysfunction, autophagy and apoptosis of cells and tissues under various pathologi...

acute fatty liver of pregnancy (aflp) is a rare entity and a potentially fatal disorder. it is reported to be more common in multiple than singleton pregnancies. sometimes it coincides with preeclampsia but the exact etiology is not yet understood. a 31-year-old g2 p1 patient admitted at 33 weeks of pregnancy with signs and symptoms of jaundice, gastroenteritis, hypertension, malaise, urinary i...

conclusions overall, coq10 was determined to have positive effects on liver injury and its related behavioral and biochemical changes. results the serum levels of alanine-aminotransferase (alt), aspartate-aminotransferase (ast), and nh4 show significant increases (p < 0.05). the groups treated with coq10 were shown to have significantly lower clinical grade of encephalopathy (p = 0.001), higher...