The highly evolutionary conserved mitogen activated protein kinase kinases 1 and 2 (MEK1/2), are known as upstream protein kinases that phosphorylate ERK1and ERK2. There are two distinct gene isoforms Mek1 and Mek2. While MEK1 and MEK2 show high homology in their kinase domains, their N termini are significantly divergent. The differential role of MEK1 and MEK 2 in cellular signaling in inflamm...

Many extracellular stimuli are converted into specific cellular responses through the activation of mitogen-activated protein kinase (MAPK) signalling pathways. MAPKs are serine/threonine protein kinases that can phoshorylate both cytoplasmic and nuclear targets.1,2 Four distinct subgroups within the MAP kinase superfamily have been described: extracellular signal-regulated kinases (ERKs), c-ju...

Mitogen-activated protein (MAP) kinases are rapidly activated in cells stimulated with various extracellular signals by dual phosphorylation of tyrosine and threonine residues. They are thought to play a pivotal role in transmitting transmembrane signals required for cell growth and differentiation. Herein we provide evidence that two distinct classes of MAP kinases, the extracellular signal-re...

Extracellular signals are transduced into cells through mitogen-activated protein kinases (MAPKs), which are activated by their upstream kinases. Recently, families of scaffolding proteins have been identified to tether specific combinations of these kinases along specific signaling pathways. Here we describe a protein, JLP (c-Jun NH2-terminal kinase-associated leucine zipper protein), which ac...