Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of ...

This review evaluates the long-term results of Levodopa therapy in Parkinson's disease upon quality of life, prolongation of survival and excess mortality. It also focuses on recent and new therapeutic approaches: Levodopa in combindation with a Dopa-decarboxylase inhibitor or MAO-B inhibitor, dopamine agonists and an active tripeptide: L-prolyl-L-leucylglycine amide (MIF-I). It ends by looking...

The spectra were recorded by a FTIR spectrometer (Brucker Equinox 55) with a MCT detector at an optical resolution of 2 cm-1 and 2 level zero-filling. For the accelerated ageing tests the quartz reaction chamber with ZnSe optic windows was placed in the sample compartment of the spectrometer. The chamber was equipped with an electric furnace enabling heating in the broad temperature range (to 9...

In the present research, properties of ultraviolet (UV) visible (daylight invisible) fluorescent coatings modified by addition SiO2 and TiO2 nanoparticles were studied. Structural, surface, mechanical changes in caused accelerated ageing analyzed. The results showed that unaged aged printed coatings. Reflectance measurements improved visual effect Furthermore, have shown did not diminish reflec...

Dimethyl sulfide (DMS) is a flavor compound, characteristic of the truffle aroma in red wines, and well-known to be fruity exhauster. DMS comes from degradation dimethyl potential (DMSP) during winemaking. Up now, little known about role closure on DMSP ageing. For that purpose, effect four micro-agglomerated wine cork closures was studied DMS/DMSP equilibrium, along with six other volatile sul...

The composition of the liquid electrolyte is a key factor in lifetime performance lithium-ion batteries. selection and quantification additives to an active field research. This study focuses on finding optimal additive combination fluoroethylene carbonate (FEC) vinylene (VC) for NMC622-Graphite cells. central goal this work accelerate experimental search large area by using Bayesian-optimizati...

apparent rise in the incidence of infertility in females and the trend shifting towards delayed child bearing brought up the concept of ovarian ageing. women in their early thirties show poor ovarian reserve which is an entity named as early ovarian ageing. early ovarian ageing is mostly genetically determined, but acquired modifiable factors like smoking, or ovarian surgery have some roles. in...

Groundnut seed priming was performed with an aqueous solution of gibberellic acid (GA3) (0, 50, 100, and 150 ppm for 18h) and accelerated aging (96 h) was done prior to drought stress (-0.4, -0.6, and -0.8 MPa), then recovered. Investigated traits were germination percentage, mean germination time, germination rate, vigor index, plumule length, radicle length, seedling length, malondialdehyde c...

Introduction Accelerated biological ageing might contribute to the higher prevalence of age-related diseases and excess mortality amongst individuals with mental disorders. Recent advances in machine learning collection high-dimensional molecular “omics” data allow for quantification age. Objectives The aim this study was use methods predict age from nuclear magnetic resonance spectroscopy meta...

BACKGROUND It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study investigated the association of socio-economic and lifestyle factors, as well as traditional and novel risk factors, with biological-ageing, as measured by telomere length, in a Glasgow based cohort that included individuals with ...