Acanthosis nigricans (AN) is a lesion affecting localized areas of the skin in persons with obesity and/or hyperinsulinemia. Biochemical mechanisms responsible for developing this hyperplastic lesion are unclear, but likely involve local cutaneous growth factors. It is associated with obesity, endocrinopathies (insulin resistance, diabetes mellitus, Cushing disease and acromegaly) and visceral ...

Acanthosis nigricans (AN) is a readily recognizable dermatological manifestation of an underlying metabolic defect like insulin resistance (IR) or obesity which is closely associated with polycystic ovarian syndrome (PCOS). The aim of the study was to compare the clinical and biochemical parameters of Indian adolescent girls with PCOS with and without AN. 58 adolescent girls in the age group of...

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Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Current understanding suggests that it is associa...

Malignant acanthosis nigricans (AN) is a rare paraneoplastic syndrome seen primarily in adults with an underlying diagnosis of gastrointestinal adenocarcinoma. Malignant AN is characterized by hyperpigmentation and velvety hyperplasia of the epidermis. This condition is generally not associated with tumors in pediatric populations or in the adrenal gland. We present a case of malignant AN in a ...

Acanthosis nigricans is characterised by hyperpigmentation and velvet like thickening of skin. It seen symmetrically involving the neck, axilla, groins, antecubital popliteal fossae, umbilical, perianal areas in advanced conditions, even dorsum hands fingers. To evaluate clinical features epidemiological factors acanthosis pre primary school children to association with body mass index, waist c...

Objectives: Acanthosis nigricans presents as black velvety plaques on flexural surfaces which is associated with obesity, T2DM and HTN. To study sites types of AN (Acanthosis Nigricans) in adolescents Vs. adults its associations. Study design & setting: This cross sectional was conducted from IstMar-31stAug 2021 at RIHS Islamabad after ethical approval. Methodology: Adolescents adult cases ...