Background:Obstetric cholestasis, or intrahepatic cholestasis of pregnancy (ICP), is a liver disease that usually presents in the third trimester pregnancy. It characterized by pruritis associated with elevated enzymes and bile acids. This condition can have potentially serious effects on fetus due to buildup serum acids resulting from obstruction flow.
 Case Overview:A 28-year-old patient...

Background: A group of adenosine triphosphate binding cassette transporter (ABCs) including ABCA1, ABCG1, ABCG4, ABCG5 and, ABCG8 induce cholesterol efflux from the cell and thereby are target genes in prevention and treatment of atherosclerosis. ABCA1, ABCG5 and, ABCG8 genes are activated by liver X receptor (LXR) and liver receptor homolog-1 (LRH-1) that play essential roles in metabolic proc...