نتایج جستجو برای: abcg1 abcg5 pyy 3

تعداد نتایج: 1812486  

2018
Claudia Guida Laura J McCulloch Mahdieh Godazgar Sam D Stephen Charlotte Baker Davide Basco Jiawen Dong Duan Chen Anne Clark Reshma D Ramracheya

AIMS The gut hormone peptide tyrosine tyrosine (PYY) is critical for maintaining islet integrity and restoring islet function following Roux-en-Y gastric bypass (RYGB). The expression of PYY and its receptors (NPYRs) in islets has been documented but not fully characterized. Modulation of islet PYY by the proteolytic enzyme dipeptidyl peptidase IV (DPP-IV) has not been investigated and the impa...

Journal: :The New England journal of medicine 2003
Rachel L Batterham Mark A Cohen Sandra M Ellis Carel W Le Roux Dominic J Withers Gary S Frost Mohammad A Ghatei Stephen R Bloom

BACKGROUND The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food intake by modulating appetite circuits in the hypothalamus. However, in obesity there is a marked resistance to the action of leptin, which greatly limits its therapeutic effectiveness. We investigate...

Journal: :Journal of lipid research 2017
Thomas Q de Aguiar Vallim Elinor Lee David J Merriott Christopher N Goulbourne Joan Cheng Angela Cheng Ayelet Gonen Ryan M Allen Elisa N D Palladino David A Ford Tisha Wang Ángel Baldán Elizabeth J Tarling

Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are restricted to epithelial type 2 (T2) pneumocytes (also called T2 cells). Clearance of surfactant is dependent upon T2 cells and macrophages. ABCG1 is highly expressed in both T2 cells and macrophages. ABCG1-deficient mice accumulate surfactan...

2012
Janine K. Kruit Nadeeja Wijesekara Clara Westwell-Roper Tim Vanmierlo Willeke de Haan Alpana Bhattacharjee Renmei Tang Cheryl L. Wellington Dieter LütJohann James D. Johnson Liam R. Brunham C. Bruce Verchere Michael R. Hayden

Cellular cholesterol homeostasis is important for normal β-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secretion. Mice lacking β-cell ABCA1 have increased islet expression of ABCG1, another cholesterol transporter implicated in β-cell function. To determine whether ABCA1 and ABCG1 have c...

2014
Farrell Cahill Yunqi Ji Danny Wadden Peyvand Amini Edward Randell Sudesh Vasdev Wayne Gulliver Guang Sun

BACKGROUND PYY is an appetite suppressing hormone. Low circulating PYY has been linked to greater BMI. However data is controversial and this association has not been verified in large human populations. OBJECTIVE The purpose of this study was to investigate if fasting serum total PYY is associated with obesity status and/or adiposity at the population level. DESIGN A total of 2094 subjects...

2007
Sumio OHTSUKI Mayu KAMOI Yuki WATANABE Hiroya SUZUKI Satoko HORI Tetsuya TERASAKI

family transport various substrates coupled with hydrolysis of ATP. The human ABC transporter superfamily consists of 49 subtypes, some of which function as drug efflux transporters (ABCB1, ABCC subfamily and ABCG2) or sterol transporters (ABCA1, ABCA7, ABCG1, ABCG5 and ABCG8). However, the role of the ABCA5-like transporters remains largely unknown. The ABCA family forms the second largest gen...

Journal: :Journal of lipid research 2009
Angel Baldán Dragana D Bojanic Peter A Edwards

Mammalian cells have developed various responses to minimize accumulation of unesterified cholesterol, as the latter can result in cell toxicity and death [reviewed in this edition by Björkhem (Björkhem, I. 2009. Are side-chain oxidized oxysterols regulators also in vivo? J. Lipid Res. In press)]. These responses include esterification to sequester excess sterol in intracellular lipid droplets,...

2017
Marjan Mahdavi-Roshan Parvin Mirmiran Mohammad Arjmand Javad Nasrollahzadeh

OBJECTIVE This study investigated the effects of garlic on brachial endothelial function and THP-1 macrophage cholesterol efflux (CE) and examined whether garlic modulates ATP-binding cassette (ABC) A1 and ABCG1 mRNA expressions in peripheral blood mononuclear cells (PBMCs) isolated from patients with coronary artery disease (CAD). METHODS In this randomized, placebo-controlled trial, patient...

Journal: :Journal of lipid research 2005
Steven L Sabol H Bryan Brewer Silvia Santamarina-Fojo

The ABC transporter ABCG1 (ATP binding cassette transporter G1), expressed in macrophages, liver, and other tissues, has been implicated in the efflux of cholesterol to high density lipoprotein. The ABCG1 gene is transcriptionally activated by cholesterol loading and activators of liver X receptors (LXRs) and retinoid X receptors (RXRs) through genomic sequences that have not been fully charact...

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