Objective: This study aims to investigate and compare the anticancer effects of carboplatin cisplatin, frequently used in cancer treatment, by loading them on albumin nanocarrier. Materials Methods: Carboplatin (CP) Cisplatin (Cis) loaded nanoparticles were synthesized using ultrasonication as CP-NPs Cis-NPs, respectively. Nanoparticle size distribution evaluated Dynamic light scattering (DLS)....

Background: The objective of this study is to evaluate combined effect of Thymoquinone (The main active component of black seeds) with Tamoxifen drug on apoptosis of human breast cancer MCF-7 cells (Noninvasive human breast cancer cell line, estrogen receptor positive). Materials and Methods: The human breast cancer MCF- 7 cells were treated with Tamoxifen (2 μM) alone or in combination with Th...

Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. Cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. In this study, we examine...

Background and objectives: Achillea is an ancient medicinal herb. The genus comprises about 100 species which are mostly distributed in northern hemisphere and some have been investigated for different biological activities. There are also several reports in Iranian Traditional Medicine (ITM) texts about its anti-tumor effect. The cytotoxic activity of the methanol extract of Achil...

Quercetin, a ubiquitous flavonol, represents a promising leading drug for development of new chemotherapeutic agents. However, its limited cytotoxicity to cancer cells hampers its clinical use. In order to obtain novel quercetin derivatives with superior cytotoxicity, seven alkylated quercetin derivatives were synthesized. Solubility of these derivatives was determined by turbidimetry. Cytotoxi...

Introduction H istone deacetylase inhibitors (HDIs), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. Valproic acid (VPA) is an HDI, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. In this study, we evaluated the effects of VPA and ionizing radiatio...