Studies on the palladium-catalyzed formation of aryl amines, aryl ethers and a-aryl carbonyl compounds from aryl halides are reported. These studies range from synthetic methodology, to detailed mechanistic analysis, to new methods one can use to screen for catalytic covalent bond formation. Improved methods for formation of aryl ethers and room temperature amination chemistry have resulted fro...

Several 2-(4-chlorophenyl)-N-(4-oxo-2-aryl(l,3,thiazolidin-3-yl))acetamides 2, N-[3-chloro-4-(2-aryl)-2-oxo-azetidinyl]-2-(4-chlorophenyl)acetamides 3, N-(4-oxo-2-aryl(1,3,-thiadiazolidin-3-yl){4-[5-oxo-2-phenyl-4-(phenylmethylene) (2imidazolinyl)phenyl}carboxamides 7 and N-(3-chloro-2-oxo-4-arylazetidinyl){4-[5-oxo-2-phenyl-4-(phenylmethylene)(2imidazolinyl)] phenyl}carboxamides 8 have been sy...

Pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) in the presence of tetramethylammonium hydroxide (TMAH) was applied to kenaf (Hibiscus cannabinus) fibers in order to clarify the chemical composition of in situ lignin. The core and bast samples obtained from the middle position of variety Chinpi-3 were pyrolyzed at 500 °C for 4 s with TMAH. The core pyrogram revealed peaks retaining th...

Abstract Tetrahydroisoquinoline alkaloids (THIQAs) are ubiquitous compounds with important pharmaceutical and biological activity. Their key N -heterocyclic structural motifs synthesised via Pictet–Spengler (P–S) reaction by norcoclaurine synthases (NCS) in plants. The synthesis of 1-aryl-tetrahydroisoquinoline has attracted increasing attention due to their antitumor antivirus activities. Here...

The course of reaction of aryl and heteroaryl sulfonamides with diphenylcarbonate (DPC) and 4-dimethylaminopyridine (DMAP) was found to depend on the pKa of the sulfonamide used. Aryl sulfonamides with pKa approximately 10 gave 4-dimethylamino-pyridinium arylsulfonyl-carbamoylides, while the more acidic heteroaryl sulfonamides (pKa approximately 8) furnished 4-dimethylaminopyridinium heteroaryl...

Herein, we developed a new procedure on 1,2-dicarbonylative cyclization of 4-aryl-1-butenes with alkyl bromides. Using simple copper catalyst, two molecules carbon monoxide were introduced into the double bond formation four C−C bonds and ring. Various α-tetralones 2,3-dihydroquinolin-4-ones formed in moderate to good yields.

Two unique organometallic halide series (Ph3P)Au(4-Me-C6H4)(CF3)(X) and (Cy3P)Au(4-F-C6H4)(CF3)(X) (X = I, Br, Cl, F) have been synthesized. The PPh3-supported complexes can undergo both C(aryl)-X and C(aryl)-CF3 reductive elimination. Mechanistic studies of thermolysis at 122 °C reveal a dramatic reactivity and kinetic selectivity dependence on halide ligand. For X = I or F, zero-order kinetic...