نتایج جستجو برای: 3 d pyrimidines
تعداد نتایج: 2219499 فیلتر نتایج به سال:
The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Add...
The recent development of a new series of carcinostatic purine analogs, the pyrazolo(3,4-d)pyrimidines (5), has led to their study as substrates and inhibitors of certain purine oxidation systems in vitro (1,4). In the course of these studies, it was observed that purified xanthine oxidase incubated in vitro with 4-aminopyrazolo(3,4-d)pyrimidine (pyrazoloadenine) resulted in its oxidation to 4a...
Synthesis and electrophilic substitutions of novel pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines.
5-Aryl-7-hydrazino-2-phenylpyrazolo[1,5-c]pyrimidines 1 were used as precursors for the preparation of a new series of 5-aryl-8-phenylpyrazolo[1,5-c]-1,2,4- triazolo[4,3-a]pyrimidines 2. The reactions of 2 with certain electrophilic reagents gave the respective 6-substituted derivatives 3-5 rather than the 7-isomeric products. Formylation of the key compounds 1 with ethyl formate yielded the fo...
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