BACKGROUND The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography. METHODS Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were co...

The recurrence rate in patients who undergo surgery for abdominal wall hernias (AWHs) is high. AWHs have been hypothesized to be a disease of the extracellular matrix, which supported by evidence showing high incidence with connective tissue disorders. This study aimed investigate most recent literature studies describing levels several matrix metalloproteinases (MMPs) blood and fascia, objecti...

Background: Rosmarinic acid (RA) is a natural phenolic compound that acts as Fyn inhibitor by 53 homology modeling of the human structure. Therefore, apoptosis mechanism related to NF-κB signaling pathway induced RA in HepG2 was investigated. Methods: The cell growth, apoptosis, and proliferation regulated various concentrations were studied. proteins expression MMP-2, MMP-9, PI3K, AKT, NF-κB, ...

Purpose: Although osteosarcoma is the most common primary malignant bone tumor among adolescents and young adults, molecular mechanisms underlying development of cancer are not fully elucidated. Cyclophosphamide (CYC) an alkylating antineoplastic agent widely used in treatment regimens various cancers chronic inflammatory diseases. The aim this study to reveal effect CYC on Saos-2 cells at leve...

Matrix metalloproteinase (MMP)-2 and MMP-9 are gelatinases that take part in several reproductive processes. The aim of this study was to measure levels MMP-2 fractionated stallion ejaculates, evaluate the association between these components semen quality, sperm longevity during cooled storage. Semen quality were assessed separately for sperm-rich fractions (HIGH), sperm-poor (LOW), whole ejac...