For almost two decades, it has been postulated that calcium-activated Cl(-) channels (CaCCs) play a role in airway epithelial Cl(-) secretion, but until recently, the molecular identity of the airway CaCC(s) was unknown. Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC. We have studied the airway bioelectrics of neonatal mice homozygous for a null allele of Tm...

Fatigue is a common problem, with high prevalence in the community, and is a common complaint for individuals seeking primary, specialty, and integrative consultation. It often defies efforts to find a specific treatable etiology and may lead to chronic impairment. Background will include discussion of chronic fatigue syndrome and depression, as differentiated from fatigue as a symptom. Also, d...

Single crystals of garnet-type trimanganese(II) dichrom-i-um(III) tris-[orthogermanate(IV)], Mn(II) (3)Cr(III) (2)(GeO(4))(3), were obtained by utilizing a chemical transport reaction. Corres-ponding to the mineral garnet with the general formula A(II) (3)B(III) (2)(SiO(4))(3), each of the four elements occupies only one crystallographically distinct position. Mn(2+) occupies the respective A p...

My research goal is to make critical software systems truly reliable and secure through formal verification. As the backbone of modern software systems, operating system (OS) kernels have great impacts on the reliability and security of today’s computing hosts. OS kernels, however, are complicated, highly concurrent, and prone to bugs. For the past several years, my research has focused on inve...

The kidneys of mammals microscopically consist of the nephrons, which can be divided into two portions, the renal corpuscles and the uriniferous tubules. The renal corpuscles are composed of the glomeruli which are covered with the Bowman’s capsules. They are localized in the outer zone of the kidney, the renal cortex, while the uriniferous tubules are composed of two portions, the proximal por...

The complex etiology of schizophrenia has prompted researchers to develop clozapine-related multitarget strategies to combat its symptoms. Here we describe a series of new 6-aminomethylbenzofuranones in an effort to find new chemical structures with balanced affinities for 5-HT2 and dopamine receptors. Through biological and computational studies of 5-HT2A and D2 receptors, we identified the re...

Two enzymes are responsible for the cleavage of pregnane side chains. A steroid-inducible oxygenase, in the presence of reduced nicotinamide adenine trinucleotide and molecular oxygen, catalyzes the conversion of progesterone into testosterone acetate. The latter ester is then hydrolyzed by an esterase to yield testosterone. The oxygenase has been partially purified and separated from the ester...

It has been established that the 16-glucosiduronate metabolites of estriol comprise the major estriol component in pregnancy plasma [ 1 ] , urine [ 1,2] and amniotic fluid [3]. However, little is known about their physiological or pathological correlations. One reason is the fact that assays for individual metabolites of estriol either do not exist or are unsuitable for practical processing of ...

ÐSeveral RGD peptidomimetics have been prepared, in a convergent way, from the common ortho-aminotyrosine template (O-substituted with an anchorage-arm or a methyl group, and aN-substituted with a ̄uorine tag for XPS analysis), and various o-aminoacid derivatives. The most ̄exible compounds have shown a biological activity similar to that of the peptide reference (RGDS) in the platelet aggregat...