Enterobacter sp. G-1 is a bacterium isolated preyiously as a chitinase-preducing bacterium. We found this bacterium also produced IVLacetylglucesaminidase and characterized that in this study. Extracellular IVLacetylglucosaminidase of 92.0kDa was purified near hemogeneity by 8.57-fold from Enterobacter sp. G-1. The eptirn-m temperature and the optimum pH of the purified iVLacetylglucosaminidase...

Lise E. Nigrovic, Richard Malley, Dewesh Agrawal, and Nathan Kuppermann, for the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics Divisions of Emergency Medicine and Infectious Diseases, Children’s Hospital Boston and Harvard Medical School, Boston, Massachusetts; Division of Emergency Medicine, Children’s National Medical Center and George Was...

Due to the lack of detailed reports of Klebsiella pneumoniae carbapenemase (KPC)-producing enterobacteria in Ontario, Canada, we perform a molecular characterization of KPC-producing Enterobacteriaceae submitted to the provincial reference laboratory from 2008 to 2011. Susceptibility profiles were accessed by E-test. Molecular types of isolates were determined by pulse-field gel electrophoresis...

The synthesis and antibacterial activity of 1beta-methylcarbapenems with quaternary ammonium groups at the C-2 position have been studied. Two types of new carbapenem derivatives have been synthesized. These 1beta-methylcarbapenems, one type having a (2S,4S)-2-[1,1-dimethyl-2-(1-piperazinyl)carbonyl]pyrrolidinio-4-+ ++ylthio group and the other type having a (2S,4S)-2-(4-carbamoylmethyl-4-methy...

The carbapenem class of ?-lactams has been optimized against Gram-negative bacteria producing extended-spectrum ?-lactamases by introducing substituents at position C2. Carbapenems are currently investigated for the treatment tuberculosis as these drugs potent covalent inhibitors l,d-transpeptidases involved in mycobacterial cell wall assembly. optimization carbapenems inactivation unusual targ...

BACKGROUND Enterobacter species are important nosocomial pathogens, and there is growing concern about their ability to develop resistance during antimicrobial therapy. However, few data are available on the clinical characteristics and outcomes of Enterobacter spontaneous bacterial peritonitis (SBP). METHODS We retrospectively identified all patients with SBP caused by Enterobacter species a...

background: based on biochemical properties, enterobacter cloacae represents a large complex of at least 13 variant species, subspecies, and genotypes that progressively identified as the most species causing hospital-acquired infections. the aim of this study was to determine the relevance between phylogenetically related strains within the e. cloacae complex and the frequency of urinary tract...

Carbapenems are one of the last lines of defense for Gram-negative pathogens, such as members of the Enterobacteriaceae. Despite the fact that most carbapenems are resistant to extended-spectrum β-lactamase (ESBL), emerging metallo-β-lactamases (MBLs), including New Delhi metallo-β-lactamase 1 (NDM-1), that can hydrolyze carbapenems have become prevalent and are frequently associated with the s...