1. One of the main problems in the field of multifunctional proteins such as ligandin is the possibility that multiple forms and isoproteins may exist. Because liver ligandin [GSH (reduced glutathione) S-transferase B] consists of equal amounts of Ya (22 000 Da) and Yc (25 000 Da) subunits, and testis ligandin, prepared by the standard technique of anion-exchange and molecular-exclusion chromat...

Inhibition of HIF-1a activity provides an important strategy for the treatment of cancer. Recently, 3-(5 0-hydroxymethyl-2 0–furyl)-1benzyl indazole (YC-1) has been identified as an anti-HIF-1a drug in cancer therapy with unclear molecular mechanism. In the present study, we aimed to investigate the effect and mechanism of YC-1 on HIF-1a in a hepatocellular carcinoma cell line under hypoxic con...

We report the 4.04-Mb draft genome sequence of Arthrobacter sp. YC-RL1, an aromatic compound-degrading bacterium. YC-RL1 could degrade a wide range of aromatic compounds, including naphthaline, 1,2,3,4-tetrachlorobenzene, fluorene, 4-nitrophenol, bisphenol A, biphenyl, and p-xylene. The genome sequence of YC-RL1 will promote the investigation of the biodegradation of aromatic compounds.

Two studies were conducted utilizing 270 chickens to evaluate the efficacy of yeast culture (YC) for both broiler and layer ayian types. In the first experiment, three dietary levels (0, 1.25, 2.50 percent) of YC were included in a nutritionally complete ration and fed to 14-day-old broiler chicks for 8 days. Body weight gain, feed consumption (g) and feed efficiency were not influenced by yeas...

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The aim of the study was to evaluate the mechanisms of HIF-1α inhibitor, YC-1, during bile duct ligation (BDL)-induced liver fibrosis in mice. Liver fibrosis was induced in mice, and YC-1 was then given intraperitoneally (50 mg/kg) once daily following 5 days. Liver injuries mice that were treated with ...

In automated container terminals (ACTs), quay cranes (QCs), guided vehicles (AGVs), and yard (AYCs) interact intensively to handle containers at seaside side. This work investigates interacting equipment in ACTs that employ AGVs with the capability of lifting a temporarily buffered transfer area front storage block. By establishing using Petri net model interaction system (EIS) for transportati...

Prostate cancer is the most frequently diagnosed cancer in men and often requires surgery. Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. IRDye 800CW was conjugated to YC-27 or an anti-PSMA anti...

A cDNA clone for the Ya subunit of glutathione transferase from rat liver was constructed in E. coli. The clone hybridized to Ya and Yc subunit messenger RNAs. On the basis of experiments involving cell-free translation and hybridization to the cloned probe, it was shown that prototype inducers of cytochrome P-450 such as phenobarbitone and 3-methylcholanthrene as well as inhibitors such as CoC...

Since the discovery of nesting whooping cranes in Wood Buffalo National Park, the Canadian Wildlife Service has conducted aerial surveys to monitor the population. Aerial survey techniques have varied over the years; however, they have generally followed the techniques used by the author since 1991. The technique involves flying a combination of circular flights and transects over known nesting...

An estimated 9,500 sandhill cranes (Grus canadensis) died in Gaines County, Texas and Roosevelt County, New Mexico between 1982 and 1987. The predominant clinical sign observed in sick cranes was their inability to hold their heads erect, both while standing and flying. Multiple muscle hemorrhages and submandibular edema were the most common lesions seen at necropsy. Mycotoxins produced by Fusa...