the overall incidence of glucose-6-phosphate dehydrogenase (g6pd) deficiency in iranian population is estimated around 10%-14.9% . g6pd deficiency is an x-linked disorder and 80% of donors are usually male. at present, donors’ blood is not routinely screened for g6pd deficiency in iran blood bank where for detecting such enzyme deficiency, reliance is placed on pre-donation data. thus, the g6pd...

Background: Due to multiple roles of albumin in the body, injection of its medicinal product as one of the therapeutic or management strategies under conditions such as severe bleeding, burns, liver failure, and neonatal hemolytic diseases is on the physicians' agenda. Considering that albumin is the most abundant plasma protein, designing an appropriate method to purify it is highly important....

Frequency of Rhesus and ABO blood groups was determined in 3012 mothers. The blood groups in order of frequency were B, O, A and AB. Only 6.2% mothers were rhesus negative. ABO haemolytie disease of the newborn (HDN) accounted for 15.7% and Rh-HDN for 12.7% of 306 neonate admitted with Jaundice. No significant difference was found in two groups when levels of serum bilirubin, exchange transfusi...

BACKGROUND Surgery in patients with sickle cell disease is associated with high morbidity. To reduce this high morbidity, different preoperative transfusion regimens were introduced. However, blood transfusion is associated with problems. This prospective study aims to establish the safety of conducting laparoscopic cholecystectomy without transfusion in sickle cell disease patients. METHODS...

BACKGROUND Most indications for whole blood transfusion are now well managed exclusively with blood component therapy, yet the use of fresh whole blood for resuscitating combat casualties has persisted in the U.S. military. METHODS Published descriptions of whole blood use in military and civilian settings were compared with use of whole blood at the 31st Combat Support Hospital (31st CSH) st...

INTRODUCTION Homozygous sickle cell carriers have an increased perioperative mortality. Some indications may justify an exchange blood transfusion to reduce the proportion of haemoglobin S. The advantages of general blood transfusion in a perioperative setting have not been proven and thus remain controversial. It is not clear whether reducing the proportion of haemoglobin S minimizes periopera...

An 11-month-old patient with idiopathic cardiomyopathy was scheduled for orthotopic heart transplantation. A perioperative exchange transfusion was performed because of elevated panel reactive antibody levels. This process was accomplished in the operating room prior to instituting cardiopulmonary bypass using a modified cardiopulmonary bypass circuit. In preparation for the procedure, the card...

In a previous study by Anderson, Smith and Walker (1961), it was observed that in four out of 100 infants undergoing exchange transfusion for haemolytic disease of the newborn, a rise of blood pyruvate occurred during the procedure. It was suggested that the rise of blood pyruvate might be due either to the metabolic action of citrate or glucose, and that this biochemical change might be relate...

Falciparum malaria may be associated with significant morbidity and mortality. The degree of mortality and morbidity usually corresponds to the degree of parasitemia. Quinine and other antimalarial drugs are relatively slow acting and not always effective owing to the presence of drug resistance falciparum. Rapid reduction of the number of circulating parasites may be required. Exchange transfu...