Purpose:When evaluated in patients with ovarian and other cancer, vintafolide (EC145), a potent folatetargeted vinca alkaloid conjugate, displayed a toxicity profile that seemed to be nonoverlapping with many standard-of-care cancer therapeutics. Itwas, therefore, hypothesized that combining vintafolidewith certain approved anticancer drugs may afford greater therapeutic efficacy compared with ...

Medicinal herbs are significant source of synthetic and herbal drugs. Before the availability of synthetic drugs, man was completely dependent on herbs as healthcare system. Medicinal herbs have been on the forefront whenever we talk about anticancer remedies. Vinca rosea (sadabahar) alkaloids, Vinblastine and Vincristine, are the most potent anticancer drugs known. Taxol isolated from Taxus br...

The Effects of Two Alkaloids Derived from Vinca rosea on the Malignant Cells of Hodgkin’s Disease, Lymphosarcoma and Acute Leukemia in Vivo Alberto M. Marmont and Eugenio E. Damasio 1 Studies of Lymphocyte Kinetics in Man Seymour Perry, George L. Irvin, 111, and Jacqueline Whang 22 The Effects of Allografts of Thymic Epithelial Reticular Cells on the Lymphoid Tissues of Neonatally Thymectomized...

Description Vinpocetine (vinpocetine-ethyl apovincaminate) was synthesized in the late 1960s from the alkaloid vincamine, extracted from the leaf of the lesser periwinkle plant (Vinca minor). Vinpocetine was made available under the trade name Cavinton in 1978 and has since been used widely in Japan, Hungary, Germany, Poland, and Russia for the treatment of cerebrovascular-related pathologies. ...

Recently detected but unidentified cytokinin activity in crown gall tumor tissue from Vinca rosea L. grown on media containing sources of reduced nitrogen has now been attributed to two adenine-type cytokinins. These compounds are glucopyranosyl derivatives of zeatin and ribosylzeatin. The substitution in each case is on the isopentenyl chain of the parent compound. Neither of these compounds h...