This article presents the development of a biosimilar mucus mixture for assessment of the effect of mucus on drug absorption. The biosimilar mucus was optimized to represent a rheological profile similar to that of porcine intestinal mucus. This was obtained with a mixture of mucin, polyacrylic acid, lipids and BSA. INTRODUCTION The viscoelastic mucus layers covering the epithelial surfaces are...

Colon has been shown to have a two-layered mucus system where the inner layer is devoid of bacteria. However, a complete overview of the mouse gastrointestinal mucus system is lacking. We now characterize mucus release, thickness, growth over time, adhesive properties, and penetrability to fluorescent beads from stomach to distal colon. Colon displayed spontaneous mucus release and all regions ...

the present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. the obtained microcapsules were discrete, spherical with free flowing properties and ...

The objective of this manuscript was to present the e-Synch system, integrating an intravaginal electronically controlled hormone delivery and sensing device with IoT platform for remote programming monitoring. Secondary objectives were demonstrate system functionality cow responses e-Synch. External components include a 3D-printed case retention wings, flexible wideband antenna, silicone membr...

OBJECTIVES To evaluate the long-term results of sigmoid vaginoplasty for Mayer-Rokitansky-Kuster-Hauser syndrome. The social and psychological acceptance of the procedure is also discussed in terms of a developing country scenario. METHODS A total of 14 patients with Mayer-Rokitansky-Kuster-Hauser syndrome were treated at our institute from January 1995 to December 2004. Sigmoid vaginoplasty ...

Cesarean rates continue to increase all over the world.Obstetric complications showed a similar increase with increasing cesarean section rate.With the many obstetric complications of increased cesarean rates, isthmocele terminology as also defined cesarean scar defecthas begun to used in the current literature. Isthmocele is a defect that appears like a dome or pocket that is localized on the ...

One of the effects chronic kidney disease is a decrease in sexual function due to long hemodialysis, where patients who undergo hemodialysis for time will experience an inability enjoy activity so that it has impact on fulfilling their needs. sexuality and change patient's pattern. Sexual dysfunction female causes increased pain women (dyspareunia) difficulty vaginal mucus, whereas men includes...