نتایج جستجو برای: utr
تعداد نتایج: 8278 فیلتر نتایج به سال:
Persistent high-risk human papillomavirus (HPV) infection is a pivotal factor in the progression of cervical cancer. In recent years, an increasing interest has emerged comprehending influence HPV on head and neck squamous cell carcinoma (HNSCC). Notably, it well established that HPV-associated HNSCC show cases with distinct molecular clinical attributes compared to HPV-negative cases. The pres...
هدف از این پژوهش بررسی چندشکلی¬های ژن میوستاتین و ارتباط آنها با صفات دوقلوزایی و رشد در150 رأس نژاد بز مرخز ایران در دو گروه، تک قلوزا و دوقلوزا بود. بطوریکه، پس از استخراجdna، از دو جفت پرایمر اختصاصی جهت تکثیر قطعات 573 و 475 جفت بازی به ترتیب برای نواحی اگزون یک، سه و 5`utr استفاده شد. قطعات 573 و 475 جفت بازی از ژن میوستاتین حاوی یک حذف شدگی5 نوکلئوتیدی (tttta/ 206)، یک جهش تک نوکلئوتیدی (...
Objective: To investigate the expression of miR-642 in gastric cancer and its mechanism proliferation migration. Methods: qRT-PCR was used to detect cancer. Dual luciferase gene reporting system verify direct regulatory effect on KRT19 3' UTR. The mRNA protein levels after transfection were detected by Western blot. IncucyteS long term dynamic cell observation. Kaplan-Meier method analyze relat...
A previous study has demonstrated a significant decrease in the TCRζ gene expression level in chronic myeloid leukemia (CML); thus, we further investigated the expression of TCRζ-regulating factors, the distribution of the TCRζ 3' untranslated region (3'-UTR) splice variants, and the expression level and correlation of the alternative splicing factor/splicing factor 2 (ASF/SF-2), FcεRIγ and ZAP...
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Abstract The microtubule-associated protein tau forms pathological neuronal filaments in Alzheimer's disease (AD) and other neurodegenerative disorders, known collectively as tauopathies. Previous studies in transgenic mouse models of AD suggest that reducing tau expressi...
Surfactant protein A (SP-A) plays an important role in host defense, the modulation of inflammatory processes, and in surfactant-related functions of the lung. The human SPA (hSP-A) locus consists of two functional genes, SP-A1 and SP-A2. Several hSP-A 5’UTR splice variants for each gene have been characterized and shown to be translated in vitro and in vivo. In this report, we investigated the...
Mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, represent the majority of the known familial breast cancer risk, yet account for only 20% of the total risk. As BRCA1 is a large gene, genetic screening of high-risk individuals is limited to the coding regions and intron-exon boundaries, which precludes the identification of mutations in non-coding and untranslated (UTR) reg...
Surfactant protein A (SP-A) plays an important role in host defense, modulation of inflammatory processes, and surfactant-related functions of the lung. The human SP-A (hSP-A) locus consists of two functional genes, SP-A1 and SP-A2. Several hSP-A 5'-untranslated region (UTR) splice variants for each gene have been characterized and shown to be translated in vitro and in vivo. In this report, we...
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