Pharmaconutrition is an area of current interest, especially concerning the advances in pharmacology nutrient-sensing receptors, as have been accomplished last 20 years. The family free fatty acid (FFA) receptors composed four members, sequentially named FFA1 to FFA4, which are activated by short long-chain acids. affinity and FFA4 for omega-3 polyunsaturated acids prompted pre-clinical clinica...

b a c k g r o u n d  & aim: the objective  of our study was to find out the awareness, inclination  and desire to apply the biostatistics as a tool in their areas of work by healthcare professionals. methods   &  materials:    a  cross-sectional   study  was  done  using  self-administered,   validated questionnaire,  among the faculty,  resident  doctors and internees  of medical  college,  ph...

objective: the aim of this study was to evaluate the non-genomic action of thyroxin on sperm kinetic and its probable use to improve sperm recovery after applying an enrichment method like “swim-up” in comparison with the available one, pentoxifylline. materials and methods: this is an experimental study. a total of 50 patients were recruited, followed by infertility consultation. conventional ...

Ribosomally produced natural products, the RiPPs, exhibit features that are potentially useful in the creation of large chemical libraries using simple mutagenesis. RiPPs are encoded on ribosomal precursor peptides, but they are extensively posttranslationally modified, endowing them with properties that are useful in drug discovery and biotechnology. In order to determine which mutations are a...

BACKGROUND Studies relating cardiovascular outcomes to dietary or blood measures of various fatty acids rely on the implicit assumptions that dietary change results in changes in blood fatty acids that, in turn, alter cardiac fatty acids. Although dietary intakes of n-3 (omega-3), n-6 (omega-6), and trans fatty acids are reflected in their concentrations in blood, there are few human data on th...

Modified nucleobases are potentially useful building blocks when containing catalytically active functionalities and could be introduced in chiral tridimensional molecules such as nucleic acids, which creates the premises for development of novel catalytic species. Herein, we describe synthesis a β-C-nucleoside bearing diol group at anomeric position, amenable metal ligand or organocatalyst. An...

it is well known that the chemical behavior of a compound is dependent upon the structure of itsmolecules. quantitative structure – activity relationship (qsar) studies and quantitative structure –property relationship (qspr) studies are active areas of chemical research that focus on the nature ofthis dependency. topological indices are the numerical value associated with chemical constitution...

Fluoride has been found to protect boronic acids from copper(i)-mediated decomposition; such findings should be very useful for the preparation of boronic acid-based carbohydrate sensors and boronic acid conjugates using the copper(i)-mediated click reaction.

Paprika Capsicum annuum L. contains useful molecules such as carotenoids and polyunsaturated fatty acids, which are considered high-value functional health ingredients. To obtain these compounds, paprika was extracted using different methods (Soxhlet, SC-CO2, SC-CO2 with co-extractant) at parameters. The results showed that the carotenoid content decreased addition of co-extractant while acid y...