The aim of the present work was to investigate the Schistosoma mansoni and Fasciola gigantica cross-reactivity between adult worms and egg homogenates of the parasites. Immunoprophylactic effects of crude Schistosoma mansoni worms and egg antigens mixed with or without saponins extracted from Atriplex nummularia were studied followed by challenge with 80 cercariae of Schistosoma mansoni. Our re...

Calli cultures derived from Ruscus aculeatus rhizomes were investigated for their potential to biosynthesize saponins. The capacity of undifferentiated tissues to form steroidal saponins is very limited, but when the calli developed organogenesis, mainly aerial shoots and roots, the saponin production increased significantly. Plantlets regenerated from aerial shoots of Ruscus calli showed a sap...

Two new sulfated triterpenoid saponins, zygophylosides Q (1) and R (2), have been isolated from the barks of Zygophyllum fabago L. Their structures were elucidated as 3beta,24,28,30-tetrahydro-urs-20-ene-24-O-sulphonyl-3-O-[beta-D-glucopyranosyl]-30-O-beta-D-glucopyranoside and 3beta,24,28,30-tetrahydro-urs-20-ene-24-O-sulphonyl-3-O-[beta-D-xylopyranosyl]-30-O-beta-D-glucopyranoside, respective...

In this study, we aimed to confirm the protective effects of garlic saponins against oxidative stress-induced cellular damage and to further elucidate the underlying mechanisms in mouse-derived C2C12 myoblasts. Relative cell viability was determined by 3-(4.5-dimethylthiazol-2-yl)-2.5 diphenyltetrazolium bromide assay. Comet assay was used to measure DNA damage and oxidative stress was determin...

Glinus lotoides. Linn is an ancient herb of India, generally known as Ciru-Ceruppadai, belonging to the family Molluginaceae. The natural plant resources and nature-derived chemical moieties are gaining the global demand to provide holistic health care to the Mankind. There is an indispensable need to explore the herbal resources to produce newer generation of drugs with great potential and min...

In traditional Chinese medicine, Panax ginseng C.A. Meyer (PG) invigorates “qi” of kidney, spleen and lung, promotes body fluids production, calms the mind to promote intelligence, while P. quinquefolium L. (PQ) supplies “qi”, nourishes “Yin”, clears fire and promotes body fluid production, both are classified as “restoratives”. P. notoginseng (Burk.) F.H. Chen (PN) removes blood stasis, stops ...

used as a representative tonic for two thousand years in the Far East countries like Korea, China, and Japan. Now, ginseng is one of the most famous and precious herbal medicines consumed around the world. Although ginseng exhibits multiple pharmacological actions in vitro or in vivo studies, its mechanisms on various efficacies are still elusive. Recent accumulating evidences show that ginseng...

Viburnum grandiflorum Wall. ex DC., is a plant of Himalaya and Hazara region of Pakistan which was screened for bioactive secondary metabolite and screen for biological activity. Preliminary phytochemical profiling indicated the presence of different classes of secondary plant metabolites such as alkaloids, terpenoids, saponins, anthraquinone. These secondary metabolites vary in types in differ...

Reactive oxygen species (ROS) are closely related to the aging process. In our previous studies, we found that the saponins from Aralia taibaiensis have potent antioxidant activity, suggesting the potential protective activity on the aging. However, the protective effect of the saponins and the possible underlying molecular mechanism remain unknown. In the present study, we employed a D-galacto...