Comparative Gene Identification-58 (CGI-58) is a member of the alpha/beta-hydrolase family of proteins. Mutations in the human CGI-58 gene are associated with Chanarin-Dorfman syndrome, a rare autosomal recessive genetic disease in which excessive triglyceride (TG) accumulation occurs in multiple tissues. In this study, we investigated the role of CGI-58 in cellular lipid metabolism in several ...

Objective: Metabolic disorders of lipoprotein commonly accompany diabetes. Several studies with a limited number patients have shown that glycemic control is related to dyslipidemia. Still, the validity these results in larger population and diabetic Turkish not well-established. Therefore, this study aimed reveal control's effect on lipid parameters relationship between Hba1c non-insulin-depen...

Heterozygous peroxisome proliferator–activated receptor(PPAR)-deficient (PPAR / ) mice were protected from high-fat diet–induced insulin resistance. To determine the impact of systemic reduction of PPARactivity on -cell function, we investigated insulin secretion in PPAR / mice on a high-fat diet. Glucoseinduced insulin secretion in PPAR / mice was impaired in vitro. The tissue triglyceride (TG...

Fenofibrate, a drug in the fibrate class of amphiphathic carboxylic acids, has multiple blood lipid modifying actions, which are beneficial to the prevention of atherosclerosis. One of its benefits is in lowering fasting and postprandial blood triglyceride (TG) concentrations. The goal of this study was to determine whether the hypotriglyceridemic actions of fenofibrate in the postprandial stat...

Paclitaxel and cisplatin (TP) are common chemotherapeutic agents extensively used for treating lung and esophageal cancers. The present study reported three patients with transient hypertriglyceridemia (HTG) following TP chemotherapy. Serum triglyceride (TG) levels returned to baseline at chemotherapy intermission. No patient had any history of HTG or any evidence of pancreatitis or other compl...

High glucocorticoid concentrations are accompanied by metabolic side effects such as high plasma triglyceride (TG) concentrations. Liver, brown adipose tissue (BAT) and white adipose tissue are important regulators of plasma TG. Exposure to 4°C reduces plasma TG concentrations, and we therefore aimed to study the interaction between glucocorticoid excess and 24 hours of exposure to 4°C on lipid...

Abstract Background The medicinal plant Citrullus colocynthis (L.) Schrad. ( C. ) may benefit patients at different phases of diabetes by attuning to contrasting situations. Our primary objective was find the mechanism(s) behind antidiabetic/anti-hyperlipidemic effects C . c olocynthis seed a queous e xtract (CCAE) in two stages type 2 (T2D) rats. Methods Fasting blood sugar (FBS) levels, body ...

CONTEXT Long-term hormone replacement therapy (HRT) with estradiol (E(2)) is associated with an altered lipid profile including unfavorable increases in triglyceride (TG) concentrations and augmented hepatic very low-density lipoprotein (VLDL)-TG production. There are indications that this effect of estrogens may be immediate. OBJECTIVE To study the in vivo effect of a single dose of E(2) on ...

Plasma phospholipid transfer protein (PLTP) interacts with HDL particles and facilitates the transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-active and low-active forms of PLTP exist. To elucidate the contribution of phospholipid transfer activity to changes in lip...

The turnover of adipose tissue components (lipids and cells) and the pathways of adipose lipid deposition have been difficult to measure in humans. We apply here a (2)H(2)O long-term labeling technique for concurrent measurement of adipose-triglyceride (TG) turnover, cell (DNA) proliferation, and de novo lipogenesis (DNL). Healthy subjects drank (2)H(2)O (70 ml/day) for 5-9 wk. Subcutaneous adi...