The purpose of this study was to review therapeutic outcomes and comorbidities of patients with Cushing's disease (CD) in a single center. We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014 (27 females and 6 males, median age 38 years, range 18-71 years). The diagnosis of Cushing's syndrome was established on the basis...

The presence of an intracranial aneurysm together with a pituitary adenoma presents tremendous risk of subarachnoid hemorrhage, during transsphenoidal surgery, particularly when the aneurysm lies near the operative field. A left supraclinoid internal carotid artery aneurysm and a clinically nonfunctioning pituitary adenoma coexisted in a 57-year-old woman. Initially, the aneurysm was treated by...

OBJECTIVE To explore the vidian nerve anatomy by endoscopy and paranasal sinus computed tomography (CT) to elucidate the appropriate surgical approach based on preoperative CT images. DESIGN Retrospective analysis. SETTING Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China. PATIENTS Sixty-seven patients underwent 106 endoscopic vidian neurecto...

p 16 Materials and Methods p 17 Results p 22 Discussion p 29 Conclusions p 33 Second study: pituitary tumor surgery Pituitary tumor surgery via transsphenoidal approach. Part I: A study comparing otorhinolaryngologists and neurosurgeons operating by transnasal route, using recording of surgical processes p 35 Abstract p 36 Materials and Methods p 37 Results p 43 Discussion p 50 Conclusions p 52...

AIM To determine the feasibility, advantages, and disadvantages of using a robot for holding and maneuvering the endoscope in transnasal transsphenoidal surgery. MATERIAL AND METHODS The system used in this study was a Stewart Platform based robotic system that was developed by Kocaeli University Department of Mechatronics Engineering for positioning and holding of endoscope. After the first ...

Hyponatremia is often seen after transsphenoidal surgery and is a source of considerable economic burden and patient-related morbidity and mortality. We performed a retrospective review of 344 patients who underwent transsphenoidal surgery at our institution between 2006 and 2012. Postoperative hyponatremia was seen in 18.0% of patients at a mean of 3.9 days postoperatively. Hyponatremia was mo...

PURPOSE Vascular complications induced by intercavernous sinus injury during dural opening in the transsphenoidal surgery may contribute to incomplete tumour resections. Preoperative neuro-imaging is of crucial importance in planning surgical approach. The aim of this study is to correlate the microanatomy of intercavernous sinuses with its contrast-enhanced magnetic resonance venography (CE-MR...

Intraoperative neurophysiologic monitoring (INM) is effective method to prevent operation-related nerve damage in various kinds of neurosurgery. In skull base surgery, there a possibility iatrogenic extraocular cranial nerves (EOCNs), which can be prevented with proper INM. We report case chondroma involving clivus and compressing pons who had intraoperative EOCN using the percutaneous needle i...

A series of 44 patients with acromegaly underwent transsphenoidal surgery between 1987 and 1996. The early postoperative mean basal GH level < 5 ng/ml or < 3 ng/ml was achieved in 43 (97.7%) or 38 (86.4%) out of 44 patients, respectively. Preoperative abnormal GH secretory response to TRH, GnRH and oral glucose administration was restored to normal both after surgery and at the time of the fina...

introduction: the co-existence of pituitary adenoma and meningioma is extremely rare. it is even rarer in patients with no previous known risk factors for either tumour. here, we present a case of synchronous non-functioning pituitary adenoma with suprasellar and olfactory groove meningiomas in a patient without previous irradiation. methods: the tumours were diagnosed on mri in the 65-year-old...