Orally administered small molecules may have important therapeutic potential in treating COVID-19 disease. The recently developed antiviral agents, Molnupiravir and Nirmatrelvir, been reported to be efficient treatments, with only moderate side effects, especially when applied the early phases of this However, drug–drug drug–transporter interactions already noted by drug development companies a...

The Na+/H+ exchangers (NHE) are a family of proteins that regulate intracellular pH, sodium levels and cell volume, contribute to the control cycle, proliferation, migration vesicle trafficking. However, despite their physiological importance, detailed molecular-level structural information for NHE has been lacking. Although number prokaryotic structures sodium/proton antiporters known, it is n...

This study characterizes different MTP1 (metal tolerance protein)/ZAT (zinc transporter) homologs involved in zinc (Zn) homeostasis plants. BLAST analysis of AtMTP1 protein against 15 plant species showed 21 homologs. These generally contain ~400 residues, six transmembrane helices and cation transporter activity (GO:0008324), which can be utilized predicting Zn uptake mechanisms. genes having ...

In this paper, the 1/4 vehicle model have been simulated. The vehicle body acceleration using optimal control has been optimized. The vehicle ride comfort is achieved by using robust control, and it has been compared with optimal control. The active suspension can help the vehicle to have a good dynamic behavioral. In this paper, two degrees of freedom dynamic vibration model of a general ve...

trauma during pregnancy is remarkably common, motor vehicle crashes are cause of hospitalized trauma during pregnancy. trauma occurs in 5% of pregnancies that appropriate high proportion of maternal and fetal mortality. motor vehicle crashes, falls, assaults, including domestic violence, are all important mechanisms of injury. motor vehicle accidents account for more than 50% of all traumas dur...

a spinal cord injury (sci) refers to any injury to the spinal cord or nerves at the end of the spinal canal that is caused by trauma instead of disease often causes permanent changes in strength, sensation and other body functions below the site of the injury. road traffic collision (rtc) or car crash occurs when a vehicle collides with another vehicle, pedestrian, animal, road debris, or other...

the present paper explores the impact of an on-board hydrogen harvesting system (fuel reformer) on the overall efficiency of a fuel-cell powered vehicle. various methods of hydrogen production for automotive applications have been discussed first. as the hydrogen production is one of the major challenges for application of proton exchange membrane (pem) fuel cells, especially in vehicular indus...

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this paper proposes a novel decision making framework for an electricity retailer to procure its electric demand in a bilateral-pool market in presence of charging and discharging of electric vehicles (evs). the operational framework is a two-stage programming model in which at the first stage, the retailer and ev aggregator do their medium-term planning. determination of retailer's optimum sel...