Hypothesis / aims of study Non-voiding activity (NVA) during the filling phase represents the motor component of the motor/sensory system in the bladder wall [1]. Muscarinic receptor antagonists and beta3 adrenergic receptor agonists are effective in the treatment of overactive bladder. How they do this is controversial. The aims of the present study were (i) to establish that the anticholinerg...

16:00: An 81 year-old woman was admitted to the emergency department with nausea, vomiting and hypotension. She had a history of hypertension, Type II Diabetes, renal insufficiency and dementia. Home medications: aspirin, furosemide, tolterodine tartrate, memantine, Valsartan, metformin, Lovastatin and niacin. On admission she presented with low grade fever 37.9, a blood pressure (BP) of 60/30 ...

Overactive bladder (OAB), a clinically defined symptom complex comprising urinary urgency, usually accompanied by urinary frequency and nocturia, with or without urgency incontinence, is common and has a markedly negative impact on the sufferer's quality of life. Following conservative and lifestyle management, the current pharmacological mainstay of treatment is antimuscarinic therapy. This re...

BACKGROUND Urinary incontinence in women is a common problem that adversely affects quality of life. PURPOSE To synthesize evidence of management of urinary incontinence in women. DATA SOURCES MEDLINE, CINAHL, and the Cochrane Library. STUDY SELECTION 96 randomized, controlled trials (RCTs) and 3 systematic reviews published in English from 1990 through May 2007. DATA EXTRACTION Using s...

The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology...

BACKGROUND No authors have investigated whether the administration of local oestrogens in addition to antimuscarinics could have a synergistic effect in the therapy of overactive bladder (OAB). OBJECTIVES To compare the efficacy of antimuscarinics alone versus antimuscarinics in combination with local oestrogens for OAB; to verify whether risk factors for lower antimuscarinic efficacy can be ...

INTRODUCTION AND OBJECTIVE Patient perception of overactive bladder (OAB) treatment outcomes can be a useful indicator of benefit and may help drive persistence on treatment, which is known to be poor in OAB. It remains unclear whether OAB patients dissatisfied with one antimuscarinic can achieve satisfaction with another and supporting data are limited. This study investigated patient-reported...