Homozygous 8 thalassemic mice received 50 U (1,660 U/kg) of recombinant human erythropoietin (rhEpo) 5 days a week for 2 weeks. Hemoglobin increased from 9.2 2 0.6 g/dL to 10.5 f 0.4 g/dL (P = .002) and hematocrit increased from 29.2% f 0.9% to 34.1% f 1.9% (P = .0014). The p minor/a globin chain synthesis ratio increased slightly but significantly between day -4 (0.75 f 0.07) and day 4 (0.81 f...

This case demonstrates the benefits of luspatercept for thalassemic patients who are unable to receive adequate blood transfusions. It acts as a selective ligand trap and inhibits TGF- signaling via Smad2/3 promote differentiation maturation late-stage erythroid precursors. Phase III clinical data showed that 33% reduction in transfusion burden from baseline was achieved. The administration cha...

Effect of the leaves suspension Cassia occidentalis on elimination excess iron from artificially overloaded rabbits was studied. Leaves C. (250mg/kg) were used for rabbits. Rabbits divided into three groups; five weeks and then treated with selected herb four weeks. Iron concentrations in serum body organs like heart, liver kidneys assayed all groups after overloading jectosol plus injections a...

Background: Thalassaemia is an emerging global public health concern. It considering as a rapidly growing major burden for low- and middle income countries. The prevalence of thalassaemia increasing in Bangladesh, indicates that thalassemia will be our country. Objective: To assess the level mental stress among parents with thalassemic child. Materials Methods: A cross-sectional study was condu...

BACKGROUND AND AIM: This study was conducted to evaluate salivary immunoglobulin A (IgA) level in thalassemic patients with periodontitis in comparison to thalassemic patients with healthy periodontium.METHODS: Seventy-five patients were included in this study and were divided into three groups, group A: 25 major thalassemic patients with mild to moderate periodontitis, group B: 25 thalassemic ...