A mild and selective C-H arylation strategy for indoles, benzofurans and benzothiophenes is described. The arylation method engages aryldiazonium salts as arylating reagents in equimolar amounts. The protocol is operationally simple, base free, moisture tolerant and air tolerant. It utilizes low palladium loadings (0.5 to 2.0 mol% Pd), short reaction times, green solvents (EtOAc/2-MeTHF or MeOH...

A series of Pd(en)X2 salts were used as catalysts for the conversion of aldoximes into nitriles and amides. Highlights of this protocol include the use of inexpensive polar solvents, including water, and moderate reaction temperatures. A high degree of selectivity in the reaction outcome was observed when using aliphatic vs. aromatic/conjugated aldoximes.

Herein is reported the direct asymmetric addition of phenol nucleophiles to benzopyrylium salts as a means to produce enantioenriched flavonoid-like compounds. This enantioselective C-C bond construction was achieved through a chiral anion phase-transfer strategy that mimics the proposed biosynthesis of this structurally diverse set of natural products. The utility of this methodology was demon...

Nitrogen-containing molecules are key scaffolds that are widely applied in organic synthesis as precursors of highly functionalized materials, and are also investigated for their biological activities. This Special Issue collects seven innovative contributions which expand our knowledge of the chemistry of nitro compounds, amines, diazonium salts, and peptides, and that provide a good overview ...

The first example o f an intramolecular Westphal condensat ion is described. To test the utility of this reaction, new benz(l)azino[2,1-a]phthalazinium salts have been prepared from appropriate dicarbonyl precursors. © 1999 Elsevier Science Ltd. All rights reserved.

A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, and undergoes cyclization into the phenanthridine core.

A concise method for the preparation of new 3,4,5,6-tetrahydropyrimidinium salts was presented in this paper. Further application of these salts in asymmetric diethylzinc addition of arylaldehydes was explored, giving the corresponding chiral second alcohols in good yields and moderate enantioselectivities.

It has been shown by TE NIJENHUIS and BERENDS2 that the benzenoid (or better: o-quinoid) subnucleus of alloxazines can be attacked photochemically. We found that with flavins the reaction products bear a hydroxyl group either in the 6 or in the 9 position of the benzenoid nucleus. The reactive species is the protonated flavin, the rate of the reaction has an optimum at pH 0 — 1. At still lower ...

The synthesis and structural characterisation of phosphine-substituted alkynylboronates is reported. A P(III)-centred alkynylboronate (2) was prepared that showed little evidence for the conjugation of the P-lone pair to the boron via the alkyne π-system, as judged by X-ray crystallography studies of 2 and a related P(V) compound, 3. In addition, corresponding alkynyltrifluoroborate salts were ...

1 Clermont Université, Université Blaise Pascal, LMGE, F-63000 Clermont-Ferrand, France 2 CNRS, UMR 6023, Laboratoire Microorganismes: Génome et Environnement, BP 80026, F63171 Aubière Cedex, France Clermont Université, Université Blaise Pascal, ICCF, F-63000 Clermont-Ferrand, France CNRS, UMR 6504, Institut de Chimie de Clermont-Ferrand, BP 80026, F-63171 Aubière Cedex, France * magalie.stauff...