The cannabinoid CB receptor has been shown to be the primary site of action for cannabinoid-induced effects on the central nervous 1 system. Activation of this receptor has proven to dampen neurotransmission and produce an overall reduction in neuronal excitability. Cannabinoid compounds like D-tetrahydrocannabinol and cannabidiol have been shown to be anticonvulsant in maximal electroshock, a ...

Abstract Continuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach continuous synthesis cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening cyclisation up to 45% yield. reactions were successfully performed u...

This work is concerned with the design of a Cavitufion Susceptibility Metef bused on the we af u uenluri tube for ihe measurement of the aciiuc cavllalion nuclei cuncentrarion in water ,smp/es as a f&nclim of the appii~d tension. The operation uf the Cuur'tarlun Strsceplibilify Meter is anui~zedand the muin consideralions Ieadinp to the proposed design are illustruted and criiicalIy discussed T...

A stable, closed, continuous-flow rotor (rotor systelll B-V) for operation at speeds up to 40,000 rplll has been developed, together with a fluid line seal that allows virus-containing solutions to flow into and out of the rotor without aerosol fOrIDation. The rotor is designed specifically for the isolation of virus particles frolll culture fluids where the mass of Illaterial to be isolated is...

way in which he interprets and s?l his world. The primitive imagery of the 1 fant with its powerful and mag'c symbolism is clearly seen here. Of does not need to agree with interpretations of the symbolism appreciate the way in which 1 therapist was able to make a re'j tionship with this boy at a level could understand and use. All thc working with children, whates: their theoretical approach, ...

BACKGROUND Knowing the time cannabis was last used is important for determining impairment in accident investigations and clinical evaluations. Two models for predicting time of last cannabis use from single plasma cannabinoid concentrations-model I, using Delta(9)-tetrahydrocannabinol (THC), and model II, using the concentration ratio of 11-nor-9-carboxy-THC (THCCOOH) to THC-were developed and...

The problems of introducing unvironmcntal sound into the compositional process arc discussed, including its acoustic character, syntactic orgmization, contextuaIly based meaning,and resultant listening patterns. Gaps in traditional discipIinary approaches in dealing with environmental sound arc identified, and an acoustic communicational model is proposed as an interdisciplinary alternative. Th...

BACKGROUND Whole-blood concentrations of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH) are approximately half of those in plasma due to high plasma protein binding and poor cannabinoid distribution into erythrocytes. Whole blood is frequently the only specimen available in forensic investigations; controlled cannabinoid administration studie...

METHODS: Ten male daily cannabis smokers received around-the-clock escalating 20-mg oral tetrahydrocannabinol (THC, dronabinol) doses (40 – 120 mg/day) for 8 days. Plasma and OF samples were simultaneously collected before, during, and after dosing. OF THC, 11-hydroxy-THC and 11-nor-9carboxy-THC (THCCOOH) were quantified by GC-MS at 0.5g/L, 0.5g/L, and 7.5-ng/L limits of quantification (LOQs), ...