Often, time dependent and dissipative material behaviour is observed simultaneously with load depending stiffness reduction. For example, filled elastomers and biological tissues belong to this class of materials. Both phenomena, i.e. viscoelasticity and damage, are incorporated into a formulation of finite strain elasticity. The phenomena either can be used together or one or the other feature...

Combining several materials (“phases”) into a composite material permits creation of new materials with tunable overall response, e.g., elastic properties, which can be related to the elastic moduli, arrangement, and concentrations of the composite’s phases. A recent advance predicts use of one phase having correctly tuned non-positive-definite elastic moduli (i.e., negative stiffness) in a two...

This paper presents the governing equations on the rectangular plate with the variation of material stiffness through their thick using higher order shear deformation theory (HSDT). The governing equations are obtained by using Hamilton's principle with regard to variation of Young's modulus in through their thick with regard sinusoidal variation of the displacement field across the thickness. ...

In this work, for better understanding of drug delivery systems, blood flow over a ceramic nanoparticle is investigated through microvessels. Drug is considered as a nanoparticle coated with the rigid ceramic. Due to the low characteristic size in the microvessel, the fluid flow is not continuum and the no-slip boundary condition cannot be applied. To solve this problem lattice Boltzmann method...

Lysosomes are key cellular organelles that play a role in catabolism by degrading extracellular and intracellular material. Specially, mechanisitic target of rapamycin complex 1(mTOR) localizes in its active form to the surface of lysosome, which regulates energy level, growth signal, and nutrient etc [1]. In addition, there are reports related to a tight crosstalk between mTORC1 activity and l...

background : previous studies have investigated different effects of muscle fatigue on body systems. however, there are no reports on the effect of fatigue protocol and its level on musculotendinous stiffness (mts) of the tricep-surae. this study was designed to compare the effects of 2 levels of submaximal fatigue contraction on mts of triceps-surae. methods: twenty female students by simple r...

This study presents an analytical investigation into the mechanical behavior of a cartilage-polydioxanone (PDS) plate composite grafts. Numerical methods are used to provide a first-order, numerical model of the flexural stiffness of a cartilage-PDS graft. Flexural stiffness is a measure of resistance to bending and is inversely related to the amount of deformation a structure may experience wh...

Microtubules--which define the shape of axons, cilia and flagella, and provide tracks for intracellular transport--can be highly bent by intracellular forces, and microtubule structure and stiffness are thought to be affected by physical constraints. Yet how microtubules tolerate the vast forces exerted on them remains unknown. Here, by using a microfluidic device, we show that microtubule stif...

Left atrial muscle extends into the proximal third of the mitral valve (MV) anterior leaflet and transient tensing of this muscle has been proposed as a mechanism aiding valve closure. If such tensing occurs, regional stiffness in the proximal anterior mitral leaflet will be greater during isovolumic contraction (IVC) than isovolumic relaxation (IVR) and this regional stiffness difference will ...

The acoustic cloaking theory of Norris [Proc. R. Soc. London, Ser. A 464, 2411-2434 (2008)] permits considerable freedom in choosing the transformation f from physical to virtual space. The standard process for defining cloak materials is to first define f and then evaluate whether the materials are practically realizable. In this paper, this process is inverted by defining desirable material p...