The dismal outcome of tuberculosis of the spine in the pre-antibiotic era has improved significantly because of the use of potent antitubercular drugs, modern diagnostic aids and advances in surgical management. MRI allows the diagnosis of a tuberculous lesion, with a sensitivity of 100% and specificity of 88%, well before deformity develops. Neurological deficit and deformity are the worst com...

Spondylodiscitis is a disease which defined as osteomyelitis of vertebral bodies and infection of intervertebral disc. Spondylodiscitis constitute approximately 3-5% of all cases of osteomyelitis. Spondylodiscitis are classified as pyogenic, granulomatous (tuberculosis, brucellosis, fungal-factor) and parasitic infections aetiologically. Tuberculosis is one of the most common reason of spinal i...

Tuberculous Meningoencephalitis (TBM) is an infectious disease of the central nervous system caused by Mycobacterium tuberculosis. It mainly involves meninges and brain parenchyma, as well spinal cord meninges. The spectrum complications TBM includes hydrocephalus, tuberculoma formation stroke. Stroke secondary to can cause irreversible damage lead poor clinical outcomes. diagnosis challenging ...

This study aimed to explore the roles of monocyte chemotactic protein 1 (MCP-1) and nuclear factor kappa B (NF-κB) in immune response to spinal tuberculosis in a New Zealand white rabbit model. Forty-eight New Zealand white rabbits were collected and divided into four groups: experimental group (n=30, spinal tuberculosis model was established), the sham group (n=15, sham operation was performed...

Background Macrophages play an important role in regulating the course of spinal tuberculosis within bone microenvironment. This study aimed to investigate differential expression miRNA macrophage-derived exosomes tuberculosis-infected microenvironment, identify miRNAs that hold potential as diagnostic markers and therapeutic targets. Methods We established cohorts for tuberculosis, collected m...

BACKGROUND There is no much information about how tuberculous lesions of the spine progress/heal; what clinical and radiological features suggest progression/healing; what is the optimal duration of antitubercular treatment; and what clinical, laboratory, and radiological investigations and their frequency should be done to monitor the disease course. AIMS The present study aimed to evaluate ...