The underlying mechanism of chronic pain is believed to be changes in excitability in spinal dorsal horn (DH) neurons that respond abnormally to peripheral input. Increased excitability in pain transmission neurons, and depression of inhibitory neurons, are widely recognized in the spinal cord of animal models of chronic pain. The possible occurrence of 2 parallel but opposing forms of synaptic...

spinal cord injury (sci) is a destructive condition that the cord can't send signals below the level of the injury. despite advances in the medical and surgical care of sci patients, no effective treatment exists for the neurological deficits of sci. cell therapy is a new approach for sci, and preclinical models demonstrate that cell transplantation can improve some secondary events throug...

Introduction: Functional MRI methods have been used to study sensorimotor processing in the Spinal cord. However, these techniques confront unwanted contributions to the measured signal from the physiological fluctuations. For the spinal cord imaging, most of the challenges are consequences of cardiac and respiratory movement artifacts that are considered as significant sources of noise, especi...

background: amylin and salmon calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. the aim of this study was to characterize receptors for amylin and salmon calcitonin functionally in the spinal cord of rats. we assessed the expression of c-fos in response to intraplantar formalin in the lumbar regions of the spinal cord in consciou...

  Background: Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord inj...

Dynamic sequential computed tomographic scanning with automatic table incrementation uses low milliampere-second technique to eliminate tube cooling delays between scanning slices and, thus, markedly shortens examination times. A total of 25 patients with spinal column trauma involving 28 levels were studied with dynamic scans and retrospectively reviewed. Dynamic studies were considerably fast...

1 2 Hybrid Voltage Sensor Imaging from Genetically Targeted Neurons in Hippocampal and 3 Spinal Cord Slices 4 5 6 Dongsheng Wang, Tiffany Poon, Shane McMahon, Samuel L. Pfaff, Lea Ziskind7 Conhaim, Baron Chanda, Meyer B. Jackson 8 9 1. Department of Physiology, University of Wisconsin, Madison, WI 53706. 10 2. Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk 11 Institute...

background and aims: one of the most common injuries around the world is the traumatic injury of the spine and spinal cord with unknown worldwide situation of traumatic spinal cord injury (tsci) affecting on the effectiveness of preventive policy programs. in addition, because of possibility of making paralysis, the potential injury to the spine could be one of the most important traumas and a ...

Processing of nociceptive information can be modulated at various levels in spinal cord that may range from changes of neurotransmitter release from primary afferent Ad or C-®bres to excitability changes of spinal interneurones or motoneurones. The site and mechanism of action of spinal analgesics has been assessed with a number of in vivo and in vitro methods with sometimes con ̄icting results....