Two of the most common signalling pathways in breast cancer are the ER (oestrogen receptor) ligand activation pathway and the E-cadherin snai1 slug EMT (epithelial-mesenchymal transition) pathway. Although these pathways have been thought to interact indirectly, the present study is the first to observe direct interactions between these pathways that involves the regulation of slug expression. ...

An experimental investigation is conducted to examine the effects of operating conditions and channel size on the liquid film thickness of vapor bubbles in adiabatic air-water flows within the slug flow regime. Acrylic test sections are fabricated to contain a single microchannel of square cross-section with hydraulic diameters of 510 μm and 1020 μm. High-speed visualizations are used to map th...

The Slug transcription factor plays an important role in epithelial-mesenchymal transformation during embryogenesis and is expressed in adult tissues during carcinogenesis. By detecting expression of a Slug-beta-galactosidase fusion protein, we have now demonstrated that Slug is also re-expressed in a variety of normal tissues in the adult mouse. Slug is expressed at relatively high levels in p...

PURPOSE The expression of E-cadherin correlates with the development, progression, and metastasis of esophageal squamous cell carcinoma (ESCC). Slug, a member of the snail family of transcriptional factors, is a newly identified suppressive transcriptional factor of E-cadherin. The purpose of the present study was to evaluate the clinical significance of E-cadherin and Slug expression in ESCC. ...

In Oil and gas productions, the severe slug is an undesired flow regime due to negative impact on production rate facility safety. This study examines riser-induced slugs’ influence a typical separation process, consisting of 3-phase gravity separator physically linked deoiling hydrocyclone. Four inflow scenarios are compared: Uncontrolled, open-loop, feasible, infeasible closed-loop anti-slug ...

The mass transfer of slug flow, a widely applied flow pattern in microreactors, is still difficult to predict mainly due the competing nature between convection and diffusion. This work focused on influence mixing mechanism performance under gas–liquid liquid–liquid both continuous slugs dispersed droplets. Colorimetric study with resazurin oxidation system was implemented, where resistance con...

The gas–liquid slug flow characteristics in a novel honeycomb microchannel reactor were investigated numerically and experimentally. Computational fluid dynamics (CFD) modeling was carried out with Comsol finite element software using the phase-field method, simulation results verified by micro-particle image velocimetry (micro-PIV) analysis. breakups of liquid slugs at bifurcations current fol...