Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert to an epithelial phenotype, by a process involving regulation of the E-cadherin-beta-catenin complex. We investigated the molecular basis of this regulation, using human colon cancer cells with abe...

Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite the anticancer capabilities of emodin observed in many cancers, including EOC, the underlying molecular mechanism remains to be elucidated. A crucial link has been discovered between the acquisition of metastatic traits and the epithelial-mesenchymal transition (EMT). The present study aimed to determine whether ...

Extensive slug-test experiments have been performed at the Hydrogeological Experimental Site (HES) of Poitiers in France, made up of moderately fractured limestones. All data are publicly available through the "H+" database, developed within the scope of the ERO program (French Environmental Research Observatory, http://hplus.ore.fr). Slug-test responses with high-frequency (> 0.12 Hz) oscillat...

OBJECTIVE To study the mechanism of early chemosensitivity and later chemoresistance of Cytarabine (Cyt) to HL-60 cells to regulate ERK/Slug signal pathway. MATERIALS AND METHODS HL-60 cells were stably transfected with NF-κBp65 siRNA，P53 up-regulated modulator of apoptosis (PUMA) siRNA (PUMA siRNA) and Slug siRNA respectively or exposed to 25 nM U0126 for 24h, then the cells were exposed to ...

Abstract A shearing-to-squeezing transition process for bubble formation in a T-junction was reported using microscopy and digital image technology. The investigations were conducted polydimethylsiloxane (PDMS) T-junction. According to the aspect ratio of air slug generation frequency, bubbles generated microchannel identified three types, namely dispersed bubble, short-slug long-slug bubble. c...

The Dictyostelium slug contains a simple anterior-posterior pattern of prestalk and prespore cells. It is likely that DIF, the morphogen which induces stalk cells, is involved in establishing this pattern. Previous work has shown that a number of distinct species of DIF are released by developing cells and that cell-associated DIF activity increases rapidly during the slug stage of development....

The epithelial-mesenchymal transition (EMT) process is believed to play a crucial role in nasopharyngeal carcinoma (NPC) progression, a squamous cell carcinoma of the head and neck with the tendency to metastasize early. At present, much attention has been given to the inducer of EMT involved in NPC progression, while antagonists have been less intensively characterized. In this study, unbiased...

We describe the discovery of two slugs, Arion subfuscus and Deroceras reticulatum, on living adult birds captured for banding at Powdermill Nature Reserve, Rector, Pennsylvania. The presence of slugs on birds suggests that bird transport might play a role in slug dispersal. Additional keywords: Gray fieldslug, Deroceras reticulatum, dusky arion slug, Arion subfuscus, common yellowthroat, Geothl...

To test the hypothesis that periodic signals and chemotaxis direct later morphogenesis in Dictyostelium discoideum, we investigated cell behavior and cell movement in slugs. Trails of neutral red-stained prestalk and anterior-like cells were recorded by high-resolution digital image processing. Neutral red-stained anterior-like cells in the prespore zone of slugs move straight forward in the di...

MicroRNAs (miRNAs or miRs) are a family of small non‑coding RNAs that regulate gene expression by the sequence-selective targeting of mRNAs, leading to translational repression or mRNA degradation, depending on the degree of complementarity with target mRNA sequences. miRNAs play a crucial role in cancer. In the case of breast tumors, several studies have demonstrated a correlation between: i) ...