Abstract Background Dynamic [ 18 F]flortaucipir PET imaging allows for more accurate quantification of specific binding compared to static in Alzheimer’s disease (AD). Besides, with dynamic flow is taken into account, which especially important longitudinal studies, because progression or drug intervention may lead changes. We aimed compare semi‐quantitative (SUVr) and quantitative (BP ND ) par...

In this paper, we present a new semi-automatic brain tissue segmentation method based on a hybrid hierarchical approach that combines a brain atlas as a priori information and a least-square support vector machine (LS-SVM). The method consists of three steps. In the first two steps, the skull is removed and the cerebrospinal fluid (CSF) is extracted. These two steps are performed using the tool...

4 Introduction 5 1.1 Large vocabulary vs. small vocabulary tasks . . . . . . . . . . . . . . . . . . . . 5 1.2 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 The SPHINX II System 8 2.1 Overview of SPHINX II . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.2 Hidden Markov Models (HMMs) . . . . . . . . . . . . . . . . . . . . . . . . . 8 Recognition Un...