PURPOSE High-risk human papilloma virus (HPV) plays a role in the development of a subset of vulvar squamous cell carcinomas. Uncertainty exists about the true impact of HPV in this tumor type because conflicting reports have been published with diverging prevalence rates. This study was done to fine tune the role of high-risk HPV infection in vulvar squamous cell carcinoma development in relat...

BACKGROUND IFN-γ and IL-2 cytokine-profiles define three functional T-cell subsets which may correlate with pathogen load in chronic intracellular infections. We therefore investigated the feasibility of the immunospot platform to rapidly enumerate T-cell subsets by single-cell IFN-γ/IL-2 cytokine-profiling and establish whether immunospot-based T-cell signatures distinguish different clinical ...

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in solid tumors. However, its role in angiogenesis in pituitary adenoma is controversial. Angiogenesis in solid tumors including pituitary adenoma is commonly evaluated by microvascular density (MVD). Here, we evaluated MVD and the role of VEGF in vascular architecture in 51 pituitary adenomas (24 nonfunctioning, 13 prolact...

The pituitary gonadotropic adenoma is an developed́ in the cells of anterior pituitary. It can be secreting releasing excess blood and urine; products its secretion are gonadostimulines (F.S.H. L.H.) or non-secreting this case only histo- cytochemical analysis will able to allow identification. We report two cases macroadenoma with LH-FSH immunostaining. Pituitary magnetic resonance imaging reve...

Adrenal gland surgery needs a multidisciplinary team including endocrinologist, radiologist, anesthesiologist, and surgeon. The indications for adrenal gland surgery include hormonal secreting and non-hormonal secreting tumors. Adrenal hormonal secreting tumors present to the anesthesiologist unique challenges requiring good preoperative evaluation, perioperative hemodynamic control, correction...

gestational trophoblastic neoplasia ( gtn) is one of the most common gynecologic tumors in our country. despite development of effective chemotherapy: some cases remain resistant and if there is only focus of tumor, resection would be indicated.we present a young woman with stage 1 persistant gtn showing no response to chemotherapy. transvaginal sonograpy revealed trophoblastic tissue in the ut...