Abstract A series of novel 4,6-dimorpholinyl-1,3,5-triazine derivatives 6a–6r were obtained through N -substitution and Claisen-Schmidt condensation. 1 H NMR, 13 C mass spectrometry used to characterize the molecular structures derivatives. The in vitro antiproliferation activity was evaluated using MTT assay against SW620 (human colon cancer cells), A549 nonsmall cell lung HeLa cervical MCF-7 ...

Recently, the subject was taken up by the first author, who confirmed the results about Simetone (VAN STEEKELENBURG, 1961) and extended them. The results described in the following sections are based upon this recent work. The substituted ureas and the symmetrical triazines are two special and important groups of herbicides. These compounds are taken up by the roots, transported via the xylem a...

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) can be efficiently mineralized with anaerobic domestic sludge, but the initial enzymatic processes involved in its transformation are unknown. To test the hypothesis that the initial reaction involves reduction of nitro group(s), we designed experiments to test the ability of a nitrate reductase (EC 1.6.6.2) to catalyze the initial reaction leading ...

2-Chloro-4,6-diamino-s-triazine (CAAT) is a metabolite of atrazine biodegradation in soils. Atrazine chlorohydrolase (AtzA) catalyzes the dechlorination of atrazine but is unreactive with CAAT. In this study, melamine deaminase (TriA), which is 98% identical to AtzA, catalyzed deamination of CAAT to produce 2-chloro-4-amino-6-hydroxy-s-triazine (CAOT). CAOT underwent dechlorination via hydroxya...

Heteracalixaromatics are a new generation of macrocyclic hosts showing a unique structure and versatile recognition properties towards various guests. Amazingly, the application of heteracalixaromatics as membrane transporters or ion channels has never been explored. We reported herein the elaborated design of a series of oxacalix[2]arene[2]triazine-based derivatives 1-10 and their ion transpor...