Stereospecific Permeability of Rat BloodBrain Barrier to Lactic Acid • Blood and whole brain C and P activities were determined in hepatectomized rats one, two, five and ten minutes after intravenous (I.V.) injection of C-labeled L-lactate or D-lactate and P-labeled rat red blood cells. Whole brain homogenate C was corrected for blood "C and chemically partitioned into "C-lactate, CO2 and other...

The simultaneous release and uptake of lactate by the heart has been observed both in vivo and ex vivo; however, the pathways underlying these observations have not been satisfactorily explained. Consequently, the purpose of this study was to test the hypothesis that hearts release lactate from glycolysis while simultaneously taking up exogenous lactate. Therefore, we determined the effects of ...

BACKGROUND Around birth, myocardial substrate supply changes from carbohydrates before birth to primarily fatty acids after birth. Parallel to these changes, the myocardium is expected to switch from the use of primarily lactate before birth to fatty acids thereafter. However, myocardial lactate uptake and oxidation around birth has not been measured in vivo. METHODS AND RESULTS We measured m...

We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer infusion along with simultaneous cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Traumatic brain injury (TBI) patients with nonpenetr...

how to cite this article: khosroshahi n, alizadeh p, khosravi m, salamati p, kamrani k. spinal fluid lactate dehydrogenase level differentiates between structural and metabolic etiologies of altered mental status in children. iran j child neurol. 2015 winter;9(1):31-36. abstract objective altered mental status is a common cause of intensive care unit admission in children. differentiating struc...

BACKGROUND A fast, proton echo-planar spectroscopic imaging (PEPSI) technique, capable of simultaneously measuring metabolites from multiple brain regions, was used to investigate the anatomical distribution and magnitude of brain lactate responses to intravenous lactate infusion among subjects with panic disorder and control subjects. METHODS Fifteen subjects with panic disorder and 10 contr...

Current understanding of lactate metabolism in fish is based almost entirely on the interpretation of concentration measurements that cannot be used to infer changes in flux. The goals of this investigation were: (1) to quantify baseline lactate fluxes in rainbow trout (Oncorhynchus mykiss) under normoxic conditions; (2) to establish how changes in rates of lactate appearance (R(a)) and disposa...

the aim of this study was to compare the effect of six weeks of volleyball specific training on the sand and hard surface (sport hall) on the resting levels and responses of lactate, creatine kinase (ck) and lactate dehydrogenase (ldh) to acute exercise in volleyball players. for this purpose, 18 male volleyball players (mean±sd; age, 23.7±3.7; weight, 75.3± 1.7) were randomly assigned to two g...