There is wide difference of opinion as to the prevalence of rickets amolng the urban child population of Great Britain. This is, in part, attributable to the divergent standards of diagnosis accepted by various clinicians; on the one hand rickets is frequently diagnosedl because the child has sweating of the head or flabby muscles or is backward without any evidence of pathological change in th...

The study is to determine the prevalence of rickets among children under five years and links with flouride contents in drinking water. Food sources and recommended adequate daily intake for vitamin D. Naivasha hospital Rift Valley Province, confounding correlations between the disease rickets in relation to flouride contents of water supplies and food. Case study design was used by comparing d...

Radiographic changes of rickets are well characterized, but no method of grading the severity of these changes has been in general use. Consequently, it is difficult to compare objectively or follow radiographic improvement. We prospectively evaluated the utility and reproducibility of a scoring method for measuring the severity of rickets. A 10-point score for radiographs of wrists and knees w...

Phosphate regulating gene with homologies to endopeptidases on the X-chromosome (PHEX) is a common cause of X-linked hypophosphatemic (XLH) rickets. Diverse PHEX gene mutations have been reported; however, gene mutations in sporadic rickets are less common than in XLH rickets. Herein, we describe a 50-year-old female patient with sporadic hypophosphatemic rickets harboring a novel splicing-site...

Overexpression of FGF23 results in hypophosphatemic rickets, which is characterized by renal phosphate wasting, inappropriately low circulating levels of the active form of vitamin D, and skeletal abnormalities. The precise mechanisms of how excess FGF23 leads to hypophosphatemic rickets are not clear. In this issue of the JCI, Bai and colleagues demonstrate that deletion or inhibition of CYP24...

Abstract Phosphopenic rickets may be caused by mutations in the PHEX gene (phosphate regulating endopeptidase homolog X-linked). Presently, more than 500 have been found to cause hypophosphatemic rickets. The authors report a clinical case of 4-year-old girl with unremarkable family history, who presented failure thrive and bowing legs. Laboratory tests showed hypophosphatemia, elevated alkalin...

Rickets is disease that occurs in growing bones in which defective mineralization occurs in both the bone and the cartilage of the epiphyseal growth plate, resulting in the retardation of growth and skeletal deformities. Rickets is more common in areas with less sunlight. However, this case report presents a case of the bony manifestation of rickets with the intake of vitamin D supplements in Y...

To cite: Singh P, Eske GS, Dhaneria M, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013009786 DESCRIPTION Vitamin D-dependent rickets type I A 6-year-old girl belonging to the lower socioeconomic class of a Muslim community, product of consanguineous marriage presented in the paediatric outpatient department with a history of progressive bowing of limbs...